Softwr

CRM · head to head

Reply.io vs Twenty

Reply.io logo

Reply.io

CRM

Multichannel sales engagement platform for email, LinkedIn, calls and SMS outreach

From
Free
Rated
-
Full reviewWebsite
Twenty logo

Twenty

CRM

Open-source CRM platform for technical teams at AI speed

From
Free
Rated
-
Full reviewWebsite

The short version

  • Each has a real cost: Reply.io multichannel features and CRM sync require the higher-priced Professional tier or above.; Twenty requires technical expertise to customize and maintain compared to no-code CRM platforms
  • They diverge on capability: Reply.io covers Multichannel sequences, Twenty covers Open-Source Framework.

Where they differ

Only the attributes on which Reply.io and Twenty actually diverge.

Attributes where Reply.io and Twenty differ
AttributeReply.ioTwenty
Pricing modelsubscriptionUnknown
Platformsweb, apiWeb, Self-hosted
Founded2014Unknown

Identical on both: starting price (Free), free tier (Yes), user rating (Not yet rated), category (CRM).

What each one covers

Drawn from each product's published feature list. An absence here means we hold no record of it - not that the product lacks it.

Only in Reply.io

  • Multichannel sequences
  • Contact database
  • AI email assistant
  • Deliverability tools
  • CRM sync
  • Reporting and analytics

Only in Twenty

  • Open-Source Framework
  • Custom Database Objects
  • Multiple View Types
  • AI Integration
  • Workflow Engine
  • Data Migration
  • API Access
  • Multi-Language Support

What people use each for

The jobs each tool is most often brought in to do.

Reply.io

  • Running multichannel outbound sequences combining email and LinkedInnot Twenty
  • Automating cold calling and SMS follow-ups alongside emailnot Twenty
  • Finding new B2B prospects from a built-in contact databasenot Twenty
  • Syncing outreach activity into an existing CRMnot Twenty

Twenty

  • Building custom CRM solutions for complex business processesnot Reply.io
  • Migrating from Salesforce or HubSpot while maintaining data ownershipnot Reply.io
  • Technical teams needing TypeScript-based customizationnot Reply.io
  • Organizations requiring self-hosted or air-gapped deploymentsnot Reply.io
  • Enterprises combining CRM with AI-powered workflowsnot Reply.io

Where each one falls short

Documented limitations, not opinions. Every one is a constraint you would hit in normal use.

Reply.io

  • Multichannel features and CRM sync require the higher-priced Professional tier or above.
  • LinkedIn and calling/SMS automation are billed as separate per-account add-ons on top of plan pricing.
  • Pricing is per user, which can raise costs quickly for larger sales teams.
  • Monthly (non-annual) billing carries a notable price premium over the advertised annual rates.

Twenty

  • Requires technical expertise to customize and maintain compared to no-code CRM platforms
  • Self-hosting increases operational overhead and infrastructure costs
  • Limited ecosystem of pre-built integrations compared to Salesforce
  • Smaller community and third-party extension library than established CRMs
  • Enterprise plan requires custom negotiation with no transparent pricing

Pricing, plan by plan

Reply.io

Free
  • FreeFree
    • Limited monthly emails
    • Basic sequence features
  • Starter$49/month
    • Email-only sequences
    • Billed annually per user
  • Professional$89/month
    • Multichannel sequences
    • CRM sync
    • Billed annually per user
  • Ultimate$139/month
    • Full AI suite
    • Highest sending limits
    • Advanced reporting and integrations

Twenty

Free
  • Pro$9/month
    • Full customization
    • Custom apps
    • AI Agents
  • Organization$19/month
    • Everything in Pro
    • Row-level permissions
    • SAML and OIDC SSO
  • Enterprise$null/year
    • Everything in Organization
    • Single-tenant isolation
    • IP allow-listing

Which should you pick?

Choose Reply.io if

  • You need multichannel sequences.
  • You want to start without paying.
  • You work on web, api.
  • You also want contact database.
Reply.io review

Choose Twenty if

  • You need open-source framework.
  • You want to start without paying.
  • You work on Web, Self-hosted.
  • You also want custom database objects.
Twenty review

Questions people ask

Is Reply.io or Twenty better?
Neither clearly leads. Reply.io starts at Free and Twenty at Free, and user ratings are close enough to be indistinguishable. Choose on capability and platform support.
Which is cheaper, Reply.io or Twenty?
Reply.io starts at Free and Twenty at Free.
Does Reply.io or Twenty run on more platforms?
Reply.io runs on web, api. Twenty runs on Web, Self-hosted.
Can I use Reply.io for free?
Both have a free tier, so you can try either at no cost before committing.
What is Reply.io best used for?
Reply.io is most often used for running multichannel outbound sequences combining email and linkedin, automating cold calling and sms follow-ups alongside email, finding new b2b prospects from a built-in contact database, syncing outreach activity into an existing crm. Of those, running multichannel outbound sequences combining email and linkedin and automating cold calling and sms follow-ups alongside email are not what Twenty is typically brought in for.
What can Reply.io do that Twenty cannot?
Reply.io covers Multichannel sequences, Contact database, AI email assistant, Deliverability tools. Twenty covers Open-Source Framework, Custom Database Objects, Multiple View Types, AI Integration.

Answered from the vendors’ own pages

Twenty: Is Twenty free or paid?

Twenty offers a 30-day free trial without credit card. Cloud plans start at $9 per user per month (Pro) when billed annually, with Organization plan at $19 per user per month.

Source
Twenty: Can I migrate data from Salesforce or HubSpot?

Yes, Twenty supports CSV and API-based migration from Salesforce and HubSpot, with support for 50,000+ records.

Source
Twenty: What programming languages does Twenty support?

Twenty is built with TypeScript and provides a TypeScript-based Apps framework for creating custom extensions.

Source
Twenty: How long does enterprise deployment take?

Enterprise deployment typically takes 1-2 weeks with Onboarding Packs or certified partners.

Source
Share

Related pages

More on Reply.io

More on Twenty

Keep looking

Other head to heads