Research · head to head
Aurelius vs OpenEye, Cadence Molecular Sciences
Aurelius
Research
UX research repository for tagging notes, building insights and finding them again years later
- From
- $49/month
- Rated
- -
OpenEye, Cadence Molecular Sciences
Research
Computational chemistry toolkits and the Orion cloud platform, now inside Cadence
- From
- On request
- Rated
- -
The short version
- Each has a real cost: Aurelius aurelius does not recruit participants or run unmoderated studies, so it is always a second tool alongside a testing or recruitment platform and never the whole research budget.; OpenEye, Cadence Molecular Sciences the free Public Domain Research Licence requires surrendering intellectual property rights and publishing results into the public domain, which rules it out for any academic group with a technology transfer office or patent ambitions.
- They diverge on capability: Aurelius covers Research repository, OpenEye, Cadence Molecular Sciences covers OMEGA.
- Prices and features above were last checked on 31 August 2026.
Where they differ
Only the attributes on which Aurelius and OpenEye, Cadence Molecular Sciences actually diverge.
| Attribute | Aurelius | OpenEye, Cadence Molecular Sciences |
|---|---|---|
| Starting price | $49/month | On request |
| Pricing model | Flat monthly fee, unlimited users | quote |
| Platforms | Web | Linux, Windows, macOS, Web, API |
Identical on both: free tier (No), user rating (Not yet rated), category (Research).
What each one covers
Drawn from each product's published feature list. An absence here means we hold no record of it - not that the product lacks it.
Only in Aurelius
- Research repository
- Analysis board
- Tagging
- Insights and recommendations
- Transcription
- AI assist
- Automatic report builder
- Universal search
Only in OpenEye, Cadence Molecular Sciences
- OMEGA
- ROCS
- ROCS X
- Orion platform
- Programmatic toolkits
- Academic routes
- Structure preparation
- Docking and scoring
What people use each for
The jobs each tool is most often brought in to do.
Aurelius
- A research team of three whose findings currently live in individual Miro boards and Google Docs that nobody outside the team can find six months laternot OpenEye, Cadence Molecular Sciences
- A product organisation that wants every designer and product manager to search past research without paying forty repository seatsnot OpenEye, Cadence Molecular Sciences
- A consultancy running discovery for multiple clients that needs tagged evidence kept separate per client but searchable internallynot OpenEye, Cadence Molecular Sciences
- A team preparing a repeat study who need to know what was already learned about the same problem two years ago before they recruit anyonenot OpenEye, Cadence Molecular Sciences
OpenEye, Cadence Molecular Sciences
- A pharmaceutical discovery team screening a multi-billion compound library by three-dimensional shape rather than by two-dimensional similaritynot Aurelius
- A computational chemist embedding conformer generation into an internal pipeline through the Python toolkitsnot Aurelius
- A university group publishing openly that can accept the public domain licence terms in exchange for zero costnot Aurelius
- A biotech scaling virtual screening on cloud compute without building its own clusternot Aurelius
Where each one falls short
Documented limitations, not opinions. Every one is a constraint you would hit in normal use.
Aurelius
- Aurelius does not recruit participants or run unmoderated studies, so it is always a second tool alongside a testing or recruitment platform and never the whole research budget.
- Integrations are thin, with Zapier, Jira and Slack rather than direct connections to the call recording and testing tools most teams already run, so getting material in often means manual upload.
- The tag vocabulary is only as good as the discipline applied to it, and repositories where several researchers invent overlapping tags become unsearchable within a year with no built-in governance to prevent it.
- Unlimited users is genuinely unlimited but permissions are basic below Enterprise, so a team that needs client-safe or stakeholder-only views has to buy the quoted tier for something that reads as a table-stakes control.
- It is a small independent vendor competing with much better funded repositories, which is a real procurement risk for an organisation storing years of research in it, and enterprise assurance material such as penetration test reports sits behind the top tier.
OpenEye, Cadence Molecular Sciences
- The free Public Domain Research Licence requires surrendering intellectual property rights and publishing results into the public domain, which rules it out for any academic group with a technology transfer office or patent ambitions.
- Free academic licences are renewable but re-evaluated annually with no guarantee of continuation, so a multi-year research programme has no assured software entitlement beyond the current year.
- OpenEye now sits inside Cadence Design Systems, whose core business is chip design, so the roadmap and licensing culture are set by a company for which molecular sciences is one growth line among several.
- Commercial pricing is entirely unpublished and structured as annual subscriptions with separate Orion compute, making total cost of a screening programme hard to forecast before contracting.
- The toolkits assume real computational chemistry expertise; they are libraries and applications for specialists, not an interface a medicinal chemist can drive without training.
Pricing, plan by plan
Aurelius
$49/month- Professional$49/month
- Unlimited users
- Unlimited projects and storage
- Notes, tags and documents
- Premium$199/month
- Everything in Professional
- Recommendations
- Universal search across projects
- Enterprise$undefined/year
- Everything in Premium
- SSO with SAML 2.0
- IP allowlisting
OpenEye, Cadence Molecular Sciences
On request- Commercial licence$undefined/year
- Annual subscription priced through Cadence sales
- Toolkits and applications licensed separately from the Orion platform
- Orion compute billed on top of software entitlements
- Academic Package$undefined/year
- Paid annual subscription for university groups under ten members
- Includes support
- Researchers retain intellectual property rights
- Public Domain Research LicenceFree
- No cost
- No support of any kind
- No intellectual property rights retained
Which should you pick?
Choose OpenEye, Cadence Molecular Sciences if
- You need omega.
- You work on Linux, Windows, macOS, Web, API.
- You also want rocs.
Questions people ask
- Is Aurelius or OpenEye, Cadence Molecular Sciences better?
- Neither clearly leads. Aurelius starts at $49/month and OpenEye, Cadence Molecular Sciences at On request, and user ratings are close enough to be indistinguishable. Choose on capability and platform support.
- Which is cheaper, Aurelius or OpenEye, Cadence Molecular Sciences?
- Aurelius starts at $49/month and OpenEye, Cadence Molecular Sciences at On request.
- Does Aurelius or OpenEye, Cadence Molecular Sciences run on more platforms?
- Aurelius runs on Web. OpenEye, Cadence Molecular Sciences runs on Linux, Windows, macOS, Web, API.
- What is Aurelius best used for?
- Aurelius is most often used for a research team of three whose findings currently live in individual miro boards and google docs that nobody outside the team can find six months later, a product organisation that wants every designer and product manager to search past research without paying forty repository seats, a consultancy running discovery for multiple clients that needs tagged evidence kept separate per client but searchable internally, a team preparing a repeat study who need to know what was already learned about the same problem two years ago before they recruit anyone. Of those, a research team of three whose findings currently live in individual miro boards and google docs that nobody outside the team can find six months later and a product organisation that wants every designer and product manager to search past research without paying forty repository seats are not what OpenEye, Cadence Molecular Sciences is typically brought in for.
- What can Aurelius do that OpenEye, Cadence Molecular Sciences cannot?
- Aurelius covers Research repository, Analysis board, Tagging, Insights and recommendations. OpenEye, Cadence Molecular Sciences covers OMEGA, ROCS, ROCS X, Orion platform.
Answered from the vendors’ own pages
Aurelius: Does the price really include unlimited users?
Yes. Professional at 49 US dollars a month and Premium at 199, both billed yearly, both with unlimited users, projects and storage.
OpenEye, Cadence Molecular Sciences: Is OpenEye still OpenEye?
It trades as OpenEye, Cadence Molecular Sciences, and is part of Cadence Design Systems following acquisition. The product names OMEGA, ROCS and Orion continue.
Aurelius: Can I run usability tests in it?
No. Aurelius stores and analyses research; it does not recruit participants or host sessions. Pair it with a testing tool.
OpenEye, Cadence Molecular Sciences: Can academics use it for free?
Yes, through the Public Domain Research Licence or a Teaching Licence, but both come with no support and no intellectual property rights. Keeping IP rights and support requires the paid Academic Package.
Aurelius: What is the difference between Professional and Premium?
Premium adds universal cross-project search, collections, recommendations and Zapier. If your value comes from finding old research, Premium is the tier that delivers it.
OpenEye, Cadence Molecular Sciences: What is ROCS X?
A machine learning enabled extension of ROCS shape search, built on the Orion platform, aimed at screening chemical spaces in the trillions of molecules.
Aurelius: Is there single sign-on?
Only on Enterprise, along with IP allowlisting, Jira and advanced permissions. Everything below is quoted separately.
OpenEye, Cadence Molecular Sciences: Is commercial pricing published?
No. Commercial licences are annual subscriptions quoted through Cadence sales, with Orion compute charged separately.
Related pages
More on OpenEye, Cadence Molecular Sciences
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