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Research · head to head

OpenEye, Cadence Molecular Sciences vs Seven Bridges

OpenEye, Cadence Molecular Sciences logo

OpenEye, Cadence Molecular Sciences

Research

Computational chemistry toolkits and the Orion cloud platform, now inside Cadence

From
On request
Rated
-
Full reviewWebsite
Seven Bridges logo

Seven Bridges

Research

Cloud bioinformatics platform and trusted research environment, sold by Velsera

From
On request
Rated
-
Full reviewWebsite

The short version

  • Each has a real cost: OpenEye, Cadence Molecular Sciences the free Public Domain Research Licence requires surrendering intellectual property rights and publishing results into the public domain, which rules it out for any academic group with a technology transfer office or patent ambitions.; Seven Bridges the parent merged into Velsera in 2023 alongside Pierian and UgenTec, so the platform now competes for roadmap attention with clinical interpretation and diagnostics products inside a private equity owned group.
  • They diverge on capability: OpenEye, Cadence Molecular Sciences covers OMEGA, Seven Bridges covers Trusted research environment.
  • Prices and features above were last checked on 31 August 2026.

Where they differ

Only the attributes on which OpenEye, Cadence Molecular Sciences and Seven Bridges actually diverge.

Attributes where OpenEye, Cadence Molecular Sciences and Seven Bridges differ
AttributeOpenEye, Cadence Molecular SciencesSeven Bridges
PlatformsLinux, Windows, macOS, Web, APIWeb, API, Cloud

Identical on both: starting price (On request), pricing model (quote), free tier (No), user rating (Not yet rated), category (Research).

What each one covers

Drawn from each product's published feature list. An absence here means we hold no record of it - not that the product lacks it.

Only in OpenEye, Cadence Molecular Sciences

  • OMEGA
  • ROCS
  • ROCS X
  • Orion platform
  • Programmatic toolkits
  • Academic routes
  • Structure preparation
  • Docking and scoring

Only in Seven Bridges

  • Trusted research environment
  • Cloud-agnostic
  • CWL pipelines
  • Compliance certifications
  • Cost prediction
  • Public data commons
  • Collaboration
  • Tool library

What people use each for

The jobs each tool is most often brought in to do.

OpenEye, Cadence Molecular Sciences

  • A pharmaceutical discovery team screening a multi-billion compound library by three-dimensional shape rather than by two-dimensional similaritynot Seven Bridges
  • A computational chemist embedding conformer generation into an internal pipeline through the Python toolkitsnot Seven Bridges
  • A university group publishing openly that can accept the public domain licence terms in exchange for zero costnot Seven Bridges
  • A biotech scaling virtual screening on cloud compute without building its own clusternot Seven Bridges

Seven Bridges

  • A cancer genomics group analysing controlled-access dbGaP data that cannot be moved to local infrastructurenot OpenEye, Cadence Molecular Sciences
  • A federal or federally funded programme that needs FedRAMP Moderate authorisation for its analysis environmentnot OpenEye, Cadence Molecular Sciences
  • A multi-institution consortium sharing pipelines and results under defined access controls rather than by emailing filesnot OpenEye, Cadence Molecular Sciences
  • A diagnostics developer building reproducible CWL pipelines that must stand up to later regulatory reviewnot OpenEye, Cadence Molecular Sciences

Where each one falls short

Documented limitations, not opinions. Every one is a constraint you would hit in normal use.

OpenEye, Cadence Molecular Sciences

  • The free Public Domain Research Licence requires surrendering intellectual property rights and publishing results into the public domain, which rules it out for any academic group with a technology transfer office or patent ambitions.
  • Free academic licences are renewable but re-evaluated annually with no guarantee of continuation, so a multi-year research programme has no assured software entitlement beyond the current year.
  • OpenEye now sits inside Cadence Design Systems, whose core business is chip design, so the roadmap and licensing culture are set by a company for which molecular sciences is one growth line among several.
  • Commercial pricing is entirely unpublished and structured as annual subscriptions with separate Orion compute, making total cost of a screening programme hard to forecast before contracting.
  • The toolkits assume real computational chemistry expertise; they are libraries and applications for specialists, not an interface a medicinal chemist can drive without training.

Seven Bridges

  • The parent merged into Velsera in 2023 alongside Pierian and UgenTec, so the platform now competes for roadmap attention with clinical interpretation and diagnostics products inside a private equity owned group.
  • Pricing is not published and splits into a platform subscription plus consumption-based cloud compute, so a heavy analysis quarter produces a bill that headcount-based budgeting does not anticipate.
  • The analysis capability itself has credible open source equivalents in Nextflow and Cromwell on raw cloud, so you are principally paying for compliance and governance rather than for the science.
  • Pipelines are built around Common Workflow Language, which is a real learning curve and a portability commitment for teams whose existing work is in other workflow languages.
  • Cloud storage of large genomic datasets accrues continuously whether or not you are analysing, and egress charges apply when moving results out, both of which are outside the subscription line.

Pricing, plan by plan

OpenEye, Cadence Molecular Sciences

On request
  • Commercial licence$undefined/year
    • Annual subscription priced through Cadence sales
    • Toolkits and applications licensed separately from the Orion platform
    • Orion compute billed on top of software entitlements
  • Academic Package$undefined/year
    • Paid annual subscription for university groups under ten members
    • Includes support
    • Researchers retain intellectual property rights
  • Public Domain Research LicenceFree
    • No cost
    • No support of any kind
    • No intellectual property rights retained

Seven Bridges

On request
  • Seven Bridges Platform$undefined/year
    • Platform subscription quoted through Velsera sales
    • Cloud compute and storage charged on consumption on top of the subscription
    • Cost predictor tools provided to estimate analysis spend in advance

Which should you pick?

Choose OpenEye, Cadence Molecular Sciences if

  • You need omega.
  • You work on Linux, Windows, macOS, Web, API.
  • You also want rocs.
OpenEye, Cadence Molecular Sciences review

Choose Seven Bridges if

  • You need trusted research environment.
  • You work on Web, API, Cloud.
  • You also want cloud-agnostic.
Seven Bridges review

Questions people ask

Is OpenEye, Cadence Molecular Sciences or Seven Bridges better?
Neither clearly leads. OpenEye, Cadence Molecular Sciences starts at On request and Seven Bridges at On request, and user ratings are close enough to be indistinguishable. Choose on capability and platform support.
Which is cheaper, OpenEye, Cadence Molecular Sciences or Seven Bridges?
OpenEye, Cadence Molecular Sciences starts at On request and Seven Bridges at On request.
Does OpenEye, Cadence Molecular Sciences or Seven Bridges run on more platforms?
OpenEye, Cadence Molecular Sciences runs on Linux, Windows, macOS, Web, API. Seven Bridges runs on Web, API, Cloud.
What is OpenEye, Cadence Molecular Sciences best used for?
OpenEye, Cadence Molecular Sciences is most often used for a pharmaceutical discovery team screening a multi-billion compound library by three-dimensional shape rather than by two-dimensional similarity, a computational chemist embedding conformer generation into an internal pipeline through the python toolkits, a university group publishing openly that can accept the public domain licence terms in exchange for zero cost, a biotech scaling virtual screening on cloud compute without building its own cluster. Of those, a pharmaceutical discovery team screening a multi-billion compound library by three-dimensional shape rather than by two-dimensional similarity and a computational chemist embedding conformer generation into an internal pipeline through the python toolkits are not what Seven Bridges is typically brought in for.
What can OpenEye, Cadence Molecular Sciences do that Seven Bridges cannot?
OpenEye, Cadence Molecular Sciences covers OMEGA, ROCS, ROCS X, Orion platform. Seven Bridges covers Trusted research environment, Cloud-agnostic, CWL pipelines, Compliance certifications.

Answered from the vendors’ own pages

OpenEye, Cadence Molecular Sciences: Is OpenEye still OpenEye?

It trades as OpenEye, Cadence Molecular Sciences, and is part of Cadence Design Systems following acquisition. The product names OMEGA, ROCS and Orion continue.

Seven Bridges: Is Seven Bridges still sold?

Yes. It is sold by Velsera, formed in 2023 when Summa Equity merged Seven Bridges with Pierian and UgenTec. The Seven Bridges name was retained for the platform.

OpenEye, Cadence Molecular Sciences: Can academics use it for free?

Yes, through the Public Domain Research Licence or a Teaching Licence, but both come with no support and no intellectual property rights. Keeping IP rights and support requires the paid Academic Package.

Seven Bridges: What compliance does it hold?

FedRAMP Moderate, SOC 2, HIPAA, GDPR, dbGaP and ISO 27001, 27017, 27018 and 27701, which is the usual reason institutions choose it over building on raw cloud.

OpenEye, Cadence Molecular Sciences: What is ROCS X?

A machine learning enabled extension of ROCS shape search, built on the Orion platform, aimed at screening chemical spaces in the trillions of molecules.

Seven Bridges: How is it priced?

Not published. Expect a platform subscription plus consumption charges for cloud compute and storage.

OpenEye, Cadence Molecular Sciences: Is commercial pricing published?

No. Commercial licences are annual subscriptions quoted through Cadence sales, with Orion compute charged separately.

Seven Bridges: Do I have to use a specific cloud?

No. The platform is cloud-agnostic and designed to bring analysis to where the data already resides.

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