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Research · head to head

GWI vs OpenEye, Cadence Molecular Sciences

GWI logo

GWI

Research

Access human insights and consumer insights from real people, instantly

From
Free
Rated
-
Full reviewWebsite
OpenEye, Cadence Molecular Sciences logo

OpenEye, Cadence Molecular Sciences

Research

Computational chemistry toolkits and the Orion cloud platform, now inside Cadence

From
On request
Rated
-
Full reviewWebsite

The short version

  • Only GWI has a free tier, so it costs nothing to try first.
  • Each has a real cost: GWI teams and Pro pricing requires contacting sales; no published rates for higher tiers; OpenEye, Cadence Molecular Sciences the free Public Domain Research Licence requires surrendering intellectual property rights and publishing results into the public domain, which rules it out for any academic group with a technology transfer office or patent ambitions.
  • Prices and features above were last checked on 31 August 2026.

Where they differ

Only the attributes on which GWI and OpenEye, Cadence Molecular Sciences actually diverge.

Attributes where GWI and OpenEye, Cadence Molecular Sciences differ
AttributeGWIOpenEye, Cadence Molecular Sciences
Starting priceFreeOn request
Pricing modelsubscriptionquote
Free tierYesNo
PlatformsWebLinux, Windows, macOS, Web, API

Identical on both: user rating (Not yet rated), category (Research).

What each one covers

Drawn from each product's published feature list. An absence here means we hold no record of it - not that the product lacks it.

Only in GWI

Nothing recorded that OpenEye, Cadence Molecular Sciences does not also cover.

Only in OpenEye, Cadence Molecular Sciences

  • OMEGA
  • ROCS
  • ROCS X
  • Orion platform
  • Programmatic toolkits
  • Academic routes
  • Structure preparation
  • Docking and scoring

What people use each for

The jobs each tool is most often brought in to do.

GWI

  • Supporting agency pitches with audience datanot OpenEye, Cadence Molecular Sciences
  • Selecting media channels with demographic insightsnot OpenEye, Cadence Molecular Sciences
  • Developing content strategies with consumer researchnot OpenEye, Cadence Molecular Sciences
  • Validating partnerships with market datanot OpenEye, Cadence Molecular Sciences

OpenEye, Cadence Molecular Sciences

  • A pharmaceutical discovery team screening a multi-billion compound library by three-dimensional shape rather than by two-dimensional similaritynot GWI
  • A computational chemist embedding conformer generation into an internal pipeline through the Python toolkitsnot GWI
  • A university group publishing openly that can accept the public domain licence terms in exchange for zero costnot GWI
  • A biotech scaling virtual screening on cloud compute without building its own clusternot GWI

Where each one falls short

Documented limitations, not opinions. Every one is a constraint you would hit in normal use.

GWI

  • Teams and Pro pricing requires contacting sales; no published rates for higher tiers
  • Enterprise solutions and custom datasets require separate consultation

OpenEye, Cadence Molecular Sciences

  • The free Public Domain Research Licence requires surrendering intellectual property rights and publishing results into the public domain, which rules it out for any academic group with a technology transfer office or patent ambitions.
  • Free academic licences are renewable but re-evaluated annually with no guarantee of continuation, so a multi-year research programme has no assured software entitlement beyond the current year.
  • OpenEye now sits inside Cadence Design Systems, whose core business is chip design, so the roadmap and licensing culture are set by a company for which molecular sciences is one growth line among several.
  • Commercial pricing is entirely unpublished and structured as annual subscriptions with separate Orion compute, making total cost of a screening programme hard to forecast before contracting.
  • The toolkits assume real computational chemistry expertise; they are libraries and applications for specialists, not an interface a medicinal chemist can drive without training.

Pricing, plan by plan

GWI

Free
  • FreeFree
    • 10 Agent Spark prompts monthly
    • Unlimited GWI Canvas decks
    • Chart generation
  • Plus$150/month
    • Unlimited Agent Spark prompts
    • Save and export charts
    • Unlimited GWI Canvas decks
  • Teams$null/month
    • Custom pricing
    • All Plus features
    • Access shared dashboards
  • Pro$null/month
    • Custom pricing
    • All Plus features
    • Unlimited platform access

OpenEye, Cadence Molecular Sciences

On request
  • Commercial licence$undefined/year
    • Annual subscription priced through Cadence sales
    • Toolkits and applications licensed separately from the Orion platform
    • Orion compute billed on top of software entitlements
  • Academic Package$undefined/year
    • Paid annual subscription for university groups under ten members
    • Includes support
    • Researchers retain intellectual property rights
  • Public Domain Research LicenceFree
    • No cost
    • No support of any kind
    • No intellectual property rights retained

Which should you pick?

Choose GWI if

  • You want to start without paying.
GWI review

Choose OpenEye, Cadence Molecular Sciences if

  • You need omega.
  • You work on Linux, Windows, macOS, Web, API.
  • You also want rocs.
OpenEye, Cadence Molecular Sciences review

Questions people ask

Is GWI or OpenEye, Cadence Molecular Sciences better?
Neither clearly leads. GWI starts at Free and OpenEye, Cadence Molecular Sciences at On request, and user ratings are close enough to be indistinguishable. Choose on capability and platform support.
Which is cheaper, GWI or OpenEye, Cadence Molecular Sciences?
GWI has a free tier; the other does not. Paid plans start at Free for GWI and On request for OpenEye, Cadence Molecular Sciences.
Does GWI or OpenEye, Cadence Molecular Sciences run on more platforms?
GWI runs on Web. OpenEye, Cadence Molecular Sciences runs on Linux, Windows, macOS, Web, API.
Can I use GWI for free?
Yes. GWI has a free tier, so you can try it without paying. OpenEye, Cadence Molecular Sciences starts at On request.
What is GWI best used for?
GWI is most often used for supporting agency pitches with audience data, selecting media channels with demographic insights, developing content strategies with consumer research, validating partnerships with market data. Of those, supporting agency pitches with audience data and selecting media channels with demographic insights are not what OpenEye, Cadence Molecular Sciences is typically brought in for.
What can GWI do that OpenEye, Cadence Molecular Sciences cannot?
OpenEye, Cadence Molecular Sciences covers OMEGA, ROCS, ROCS X, Orion platform.

Answered from the vendors’ own pages

GWI: Is there a free GWI plan?

Yes, GWI offers a free tier with 10 Agent Spark prompts monthly and unlimited GWI Canvas decks.

Source
OpenEye, Cadence Molecular Sciences: Is OpenEye still OpenEye?

It trades as OpenEye, Cadence Molecular Sciences, and is part of Cadence Design Systems following acquisition. The product names OMEGA, ROCS and Orion continue.

GWI: What is the difference between GWI Plus, Teams, and Pro?

Plus costs $150/user/month with unlimited prompts and 50K profiling points. Teams is custom-priced with all Plus features plus shared dashboards and multi-user discounts. Pro is custom-priced with unlimited access, up to 250K profiling points, and advanced research tools.

Source
OpenEye, Cadence Molecular Sciences: Can academics use it for free?

Yes, through the Public Domain Research Licence or a Teaching Licence, but both come with no support and no intellectual property rights. Keeping IP rights and support requires the paid Academic Package.

GWI: How much does GWI charge for annual billing?

GWI offers a 15% discount for annual commitments. Plus annual pricing is $1,500/user annually (equivalent to $125/user/month).

Source
OpenEye, Cadence Molecular Sciences: What is ROCS X?

A machine learning enabled extension of ROCS shape search, built on the Orion platform, aimed at screening chemical spaces in the trillions of molecules.

OpenEye, Cadence Molecular Sciences: Is commercial pricing published?

No. Commercial licences are annual subscriptions quoted through Cadence sales, with Orion compute charged separately.

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