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Research · head to head

Greenphire vs OpenEye, Cadence Molecular Sciences

Greenphire logo

Greenphire

Research

Clinical trial participant payments, reimbursement and travel, now part of Suvoda

From
On request
Rated
-
Full reviewWebsite
OpenEye, Cadence Molecular Sciences logo

OpenEye, Cadence Molecular Sciences

Research

Computational chemistry toolkits and the Orion cloud platform, now inside Cadence

From
On request
Rated
-
Full reviewWebsite

The short version

  • Each has a real cost: Greenphire the standalone greenphire.com site now redirects to Suvoda and the brands have been integrated, so buyers are contracting with a randomisation and supply vendor and should expect cross selling rather than an independent payments specialist.; OpenEye, Cadence Molecular Sciences the free Public Domain Research Licence requires surrendering intellectual property rights and publishing results into the public domain, which rules it out for any academic group with a technology transfer office or patent ambitions.
  • They diverge on capability: Greenphire covers ClinCard, OpenEye, Cadence Molecular Sciences covers OMEGA.
  • Prices and features above were last checked on 31 August 2026.

Where they differ

Only the attributes on which Greenphire and OpenEye, Cadence Molecular Sciences actually diverge.

Attributes where Greenphire and OpenEye, Cadence Molecular Sciences differ
AttributeGreenphireOpenEye, Cadence Molecular Sciences
PlatformsWeb, iOS, AndroidLinux, Windows, macOS, Web, API

Identical on both: starting price (On request), pricing model (quote), free tier (No), user rating (Not yet rated), category (Research).

What each one covers

Drawn from each product's published feature list. An absence here means we hold no record of it - not that the product lacks it.

Only in Greenphire

  • ClinCard
  • Direct to bank payment
  • Expense reimbursement
  • Travel and logistics
  • Site payments
  • Budgeting and benchmarking
  • Tax handling

Only in OpenEye, Cadence Molecular Sciences

  • OMEGA
  • ROCS
  • ROCS X
  • Orion platform
  • Programmatic toolkits
  • Academic routes
  • Structure preparation
  • Docking and scoring

What people use each for

The jobs each tool is most often brought in to do.

Greenphire

  • A global Phase III trial paying stipends across many countries where participants cannot practically be reimbursed by sponsor accounts payablenot OpenEye, Cadence Molecular Sciences
  • A decentralised or hybrid trial where participants travel long distances and the sponsor funds flights and accommodationnot OpenEye, Cadence Molecular Sciences
  • A trial in a population where slow reimbursement drives dropout and same day payment materially helps retentionnot OpenEye, Cadence Molecular Sciences
  • A sponsor that wants site payment milestones and participant payments handled by one vendor rather than twonot OpenEye, Cadence Molecular Sciences

OpenEye, Cadence Molecular Sciences

  • A pharmaceutical discovery team screening a multi-billion compound library by three-dimensional shape rather than by two-dimensional similaritynot Greenphire
  • A computational chemist embedding conformer generation into an internal pipeline through the Python toolkitsnot Greenphire
  • A university group publishing openly that can accept the public domain licence terms in exchange for zero costnot Greenphire
  • A biotech scaling virtual screening on cloud compute without building its own clusternot Greenphire

Where each one falls short

Documented limitations, not opinions. Every one is a constraint you would hit in normal use.

Greenphire

  • The standalone greenphire.com site now redirects to Suvoda and the brands have been integrated, so buyers are contracting with a randomisation and supply vendor and should expect cross selling rather than an independent payments specialist.
  • Nothing is published on price, and the typical shape of a platform fee plus per participant and per transaction charges means the cost of a trial is not knowable until enrolment is known.
  • Payment method availability varies sharply by country, so a global protocol may end up with card payments in some regions and slow manual processes in others, which undermines the retention argument that justified the purchase.
  • Sites bear the administrative work of enrolling participants and triggering payments but are not the buyer, so adoption depends on the sponsor mandating it and site resistance is a real implementation risk.
  • Participant payments create tax reporting obligations that differ per jurisdiction, and the tooling helps but does not remove sponsor liability, so legal and finance review is required in every country the trial runs in.

OpenEye, Cadence Molecular Sciences

  • The free Public Domain Research Licence requires surrendering intellectual property rights and publishing results into the public domain, which rules it out for any academic group with a technology transfer office or patent ambitions.
  • Free academic licences are renewable but re-evaluated annually with no guarantee of continuation, so a multi-year research programme has no assured software entitlement beyond the current year.
  • OpenEye now sits inside Cadence Design Systems, whose core business is chip design, so the roadmap and licensing culture are set by a company for which molecular sciences is one growth line among several.
  • Commercial pricing is entirely unpublished and structured as annual subscriptions with separate Orion compute, making total cost of a screening programme hard to forecast before contracting.
  • The toolkits assume real computational chemistry expertise; they are libraries and applications for specialists, not an interface a medicinal chemist can drive without training.

Pricing, plan by plan

Greenphire

On request
  • Greenphire Patient Payments$undefined/year
    • Priced per study through a sales process
    • Typically a platform fee plus per participant and per transaction charges
    • Funding of the payment float is separate from the software fee

OpenEye, Cadence Molecular Sciences

On request
  • Commercial licence$undefined/year
    • Annual subscription priced through Cadence sales
    • Toolkits and applications licensed separately from the Orion platform
    • Orion compute billed on top of software entitlements
  • Academic Package$undefined/year
    • Paid annual subscription for university groups under ten members
    • Includes support
    • Researchers retain intellectual property rights
  • Public Domain Research LicenceFree
    • No cost
    • No support of any kind
    • No intellectual property rights retained

Which should you pick?

Choose Greenphire if

  • You need clincard.
  • You work on Web, iOS, Android.
  • You also want direct to bank payment.
Greenphire review

Choose OpenEye, Cadence Molecular Sciences if

  • You need omega.
  • You work on Linux, Windows, macOS, Web, API.
  • You also want rocs.
OpenEye, Cadence Molecular Sciences review

Questions people ask

Is Greenphire or OpenEye, Cadence Molecular Sciences better?
Neither clearly leads. Greenphire starts at On request and OpenEye, Cadence Molecular Sciences at On request, and user ratings are close enough to be indistinguishable. Choose on capability and platform support.
Which is cheaper, Greenphire or OpenEye, Cadence Molecular Sciences?
Greenphire starts at On request and OpenEye, Cadence Molecular Sciences at On request.
Does Greenphire or OpenEye, Cadence Molecular Sciences run on more platforms?
Greenphire runs on Web, iOS, Android. OpenEye, Cadence Molecular Sciences runs on Linux, Windows, macOS, Web, API.
What is Greenphire best used for?
Greenphire is most often used for a global phase iii trial paying stipends across many countries where participants cannot practically be reimbursed by sponsor accounts payable, a decentralised or hybrid trial where participants travel long distances and the sponsor funds flights and accommodation, a trial in a population where slow reimbursement drives dropout and same day payment materially helps retention, a sponsor that wants site payment milestones and participant payments handled by one vendor rather than two. Of those, a global phase iii trial paying stipends across many countries where participants cannot practically be reimbursed by sponsor accounts payable and a decentralised or hybrid trial where participants travel long distances and the sponsor funds flights and accommodation are not what OpenEye, Cadence Molecular Sciences is typically brought in for.
What can Greenphire do that OpenEye, Cadence Molecular Sciences cannot?
Greenphire covers ClinCard, Direct to bank payment, Expense reimbursement, Travel and logistics. OpenEye, Cadence Molecular Sciences covers OMEGA, ROCS, ROCS X, Orion platform.

Answered from the vendors’ own pages

Greenphire: Is Greenphire still sold?

Yes, as Greenphire Patient Payments on the Suvoda platform. The independent website and social presence have been consolidated into Suvoda.

OpenEye, Cadence Molecular Sciences: Is OpenEye still OpenEye?

It trades as OpenEye, Cadence Molecular Sciences, and is part of Cadence Design Systems following acquisition. The product names OMEGA, ROCS and Orion continue.

Greenphire: What is ClinCard?

The reloadable debit card Greenphire issues to participants. Greenphire Patient Payments was formerly known as ClinCard.

OpenEye, Cadence Molecular Sciences: Can academics use it for free?

Yes, through the Public Domain Research Licence or a Teaching Licence, but both come with no support and no intellectual property rights. Keeping IP rights and support requires the paid Academic Package.

Greenphire: Does it publish pricing?

No. Pricing is per study and quoted through sales, and funding the payments themselves is separate from the software fee.

OpenEye, Cadence Molecular Sciences: What is ROCS X?

A machine learning enabled extension of ROCS shape search, built on the Orion platform, aimed at screening chemical spaces in the trillions of molecules.

Greenphire: Can it pay participants outside the United States?

Yes, in more than thirty currencies, but the available payment method depends on the country.

OpenEye, Cadence Molecular Sciences: Is commercial pricing published?

No. Commercial licences are annual subscriptions quoted through Cadence sales, with Orion compute charged separately.

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