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Research · head to head

Labguru vs OpenEye, Cadence Molecular Sciences

Labguru logo

Labguru

Research

Electronic lab notebook, LIMS and inventory in one system, now sold under the Cenevo group

From
On request
Rated
-
Full reviewWebsite
OpenEye, Cadence Molecular Sciences logo

OpenEye, Cadence Molecular Sciences

Research

Computational chemistry toolkits and the Orion cloud platform, now inside Cadence

From
On request
Rated
-
Full reviewWebsite

The short version

  • Each has a real cost: Labguru ownership changed twice in short order, to Battery Ventures in 2024 and then into the Cenevo brand with Titian Software in 2025, so the medium-term roadmap is a group strategy decision rather than a product one and buyers should ask directly what happens to the notebook.; OpenEye, Cadence Molecular Sciences the free Public Domain Research Licence requires surrendering intellectual property rights and publishing results into the public domain, which rules it out for any academic group with a technology transfer office or patent ambitions.
  • They diverge on capability: Labguru covers Combined ELN and LIMS, OpenEye, Cadence Molecular Sciences covers OMEGA.
  • Prices and features above were last checked on 31 August 2026.

Where they differ

Only the attributes on which Labguru and OpenEye, Cadence Molecular Sciences actually diverge.

Attributes where Labguru and OpenEye, Cadence Molecular Sciences differ
AttributeLabguruOpenEye, Cadence Molecular Sciences
PlatformsWeb, iOS, Android, On-premiseLinux, Windows, macOS, Web, API

Identical on both: starting price (On request), pricing model (quote), free tier (No), user rating (Not yet rated), category (Research).

What each one covers

Drawn from each product's published feature list. An absence here means we hold no record of it - not that the product lacks it.

Only in Labguru

  • Combined ELN and LIMS
  • Validated cloud hosting
  • Inventory and stock
  • Chemistry module
  • Equipment management
  • Electronic batch records
  • Label Wizard
  • API and developer tools

Only in OpenEye, Cadence Molecular Sciences

  • OMEGA
  • ROCS
  • ROCS X
  • Orion platform
  • Programmatic toolkits
  • Academic routes
  • Structure preparation
  • Docking and scoring

What people use each for

The jobs each tool is most often brought in to do.

Labguru

  • A biotech that wants experiment records and sample inventory in one system instead of paying for an ELN and a LIMS separatelynot OpenEye, Cadence Molecular Sciences
  • A chemistry group needing structure registration attached to the experiment rather than in a standalone databasenot OpenEye, Cadence Molecular Sciences
  • A contract research organisation that must show sample traceability from receipt to reported result during a client auditnot OpenEye, Cadence Molecular Sciences
  • An academic institute standardising dozens of small labs off shared spreadsheets and paper notebooks onto one searchable recordnot OpenEye, Cadence Molecular Sciences

OpenEye, Cadence Molecular Sciences

  • A pharmaceutical discovery team screening a multi-billion compound library by three-dimensional shape rather than by two-dimensional similaritynot Labguru
  • A computational chemist embedding conformer generation into an internal pipeline through the Python toolkitsnot Labguru
  • A university group publishing openly that can accept the public domain licence terms in exchange for zero costnot Labguru
  • A biotech scaling virtual screening on cloud compute without building its own clusternot Labguru

Where each one falls short

Documented limitations, not opinions. Every one is a constraint you would hit in normal use.

Labguru

  • Ownership changed twice in short order, to Battery Ventures in 2024 and then into the Cenevo brand with Titian Software in 2025, so the medium-term roadmap is a group strategy decision rather than a product one and buyers should ask directly what happens to the notebook.
  • The validated GxP hosting option is a separate commercial line, not a configuration setting, so a lab that discovers mid-project that it needs a validated instance faces a new contract and a new price rather than an upgrade.
  • Being both an ELN and a LIMS means it is shallower than dedicated tools in each role; high-throughput sample management and deep bioinformatics workflows both hit limits that a specialist would not.
  • No pricing is published at all, and modules such as chemistry, batch records and equipment are quoted on top, so the real annual figure only appears after a sales process.
  • Validation, SOPs and periodic revalidation after vendor releases are the customer obligation on a regulated instance, and cloud release cadence means that revalidation is a recurring internal cost that never appears on the vendor quote.

OpenEye, Cadence Molecular Sciences

  • The free Public Domain Research Licence requires surrendering intellectual property rights and publishing results into the public domain, which rules it out for any academic group with a technology transfer office or patent ambitions.
  • Free academic licences are renewable but re-evaluated annually with no guarantee of continuation, so a multi-year research programme has no assured software entitlement beyond the current year.
  • OpenEye now sits inside Cadence Design Systems, whose core business is chip design, so the roadmap and licensing culture are set by a company for which molecular sciences is one growth line among several.
  • Commercial pricing is entirely unpublished and structured as annual subscriptions with separate Orion compute, making total cost of a screening programme hard to forecast before contracting.
  • The toolkits assume real computational chemistry expertise; they are libraries and applications for specialists, not an interface a medicinal chemist can drive without training.

Pricing, plan by plan

Labguru

On request
  • Labguru$undefined/year
    • Priced per user per year on quotation with volume tiers
    • ELN, LIMS and inventory in the base platform
    • Chemistry, batch records and equipment modules quoted separately

OpenEye, Cadence Molecular Sciences

On request
  • Commercial licence$undefined/year
    • Annual subscription priced through Cadence sales
    • Toolkits and applications licensed separately from the Orion platform
    • Orion compute billed on top of software entitlements
  • Academic Package$undefined/year
    • Paid annual subscription for university groups under ten members
    • Includes support
    • Researchers retain intellectual property rights
  • Public Domain Research LicenceFree
    • No cost
    • No support of any kind
    • No intellectual property rights retained

Which should you pick?

Choose Labguru if

  • You need combined eln and lims.
  • You work on Web, iOS, Android, On-premise.
  • You also want validated cloud hosting.
Labguru review

Choose OpenEye, Cadence Molecular Sciences if

  • You need omega.
  • You work on Linux, Windows, macOS, Web, API.
  • You also want rocs.
OpenEye, Cadence Molecular Sciences review

Questions people ask

Is Labguru or OpenEye, Cadence Molecular Sciences better?
Neither clearly leads. Labguru starts at On request and OpenEye, Cadence Molecular Sciences at On request, and user ratings are close enough to be indistinguishable. Choose on capability and platform support.
Which is cheaper, Labguru or OpenEye, Cadence Molecular Sciences?
Labguru starts at On request and OpenEye, Cadence Molecular Sciences at On request.
Does Labguru or OpenEye, Cadence Molecular Sciences run on more platforms?
Labguru runs on Web, iOS, Android, On-premise. OpenEye, Cadence Molecular Sciences runs on Linux, Windows, macOS, Web, API.
What is Labguru best used for?
Labguru is most often used for a biotech that wants experiment records and sample inventory in one system instead of paying for an eln and a lims separately, a chemistry group needing structure registration attached to the experiment rather than in a standalone database, a contract research organisation that must show sample traceability from receipt to reported result during a client audit, an academic institute standardising dozens of small labs off shared spreadsheets and paper notebooks onto one searchable record. Of those, a biotech that wants experiment records and sample inventory in one system instead of paying for an eln and a lims separately and a chemistry group needing structure registration attached to the experiment rather than in a standalone database are not what OpenEye, Cadence Molecular Sciences is typically brought in for.
What can Labguru do that OpenEye, Cadence Molecular Sciences cannot?
Labguru covers Combined ELN and LIMS, Validated cloud hosting, Inventory and stock, Chemistry module. OpenEye, Cadence Molecular Sciences covers OMEGA, ROCS, ROCS X, Orion platform.

Answered from the vendors’ own pages

Labguru: Who owns Labguru now?

Battery Ventures acquired it in April 2024. Since July 2025 it operates under the Cenevo brand following a merger with Titian Software.

OpenEye, Cadence Molecular Sciences: Is OpenEye still OpenEye?

It trades as OpenEye, Cadence Molecular Sciences, and is part of Cadence Design Systems following acquisition. The product names OMEGA, ROCS and Orion continue.

Labguru: Is it an ELN or a LIMS?

Both, in one product. That is the main reason labs choose it, and also why it is shallower than a specialist in each role.

OpenEye, Cadence Molecular Sciences: Can academics use it for free?

Yes, through the Public Domain Research Licence or a Teaching Licence, but both come with no support and no intellectual property rights. Keeping IP rights and support requires the paid Academic Package.

Labguru: Does it support GxP work?

Yes, through a separately contracted validated cloud instance. Validation for your intended use remains your responsibility.

OpenEye, Cadence Molecular Sciences: What is ROCS X?

A machine learning enabled extension of ROCS shape search, built on the Orion platform, aimed at screening chemical spaces in the trillions of molecules.

Labguru: Is pricing published?

No. It is quoted per user per year, with modules and validated hosting priced on top.

OpenEye, Cadence Molecular Sciences: Is commercial pricing published?

No. Commercial licences are annual subscriptions quoted through Cadence sales, with Orion compute charged separately.

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