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Healthcare · head to head

OpenClinica vs TherapyNotes

OpenClinica logo

OpenClinica

Healthcare

Clinical trial EDC with a genuinely open source community edition alongside a quoted commercial platform

From
On request
Rated
-
Full reviewWebsite
TherapyNotes logo

TherapyNotes

Healthcare

EHR and practice management for therapists

From
$39/month
Rated
-
Full reviewWebsite

The short version

  • Each has a real cost: OpenClinica the free community edition is a different and older product line from the commercial platform, so evaluating the open source build tells you little about what the paid product actually does.; TherapyNotes no API access, preventing integration with external systems
  • They diverge on capability: OpenClinica covers Open source community edition, TherapyNotes covers Electronic Health Records.
  • Prices and features above were last checked on 31 August 2026.

Where they differ

Only the attributes on which OpenClinica and TherapyNotes actually diverge.

Attributes where OpenClinica and TherapyNotes differ
AttributeOpenClinicaTherapyNotes
Starting priceOn request$39/month
Pricing modelquotesubscription
PlatformsWeb, Self-hosted, iOS, AndroidWeb
FoundedUnknown2010

Identical on both: free tier (No), user rating (Not yet rated), category (Healthcare).

What each one covers

Drawn from each product's published feature list. An absence here means we hold no record of it - not that the product lacks it.

Only in OpenClinica

  • Open source community edition
  • Electronic data capture
  • eConsent
  • eCOA and ePRO
  • Randomisation
  • EHR-to-EDC
  • Audit trail
  • Reporting and analytics

Only in TherapyNotes

  • Electronic Health Records
  • Scheduling
  • Billing
  • Patient Portal
  • Telehealth
  • Outcome Tracking
  • Clearinghouses
  • Insurance

What people use each for

The jobs each tool is most often brought in to do.

OpenClinica

  • An academic coordinating centre running investigator-initiated trials that needs Part 11 compliant capture without an enterprise eClinical budgetnot TherapyNotes
  • A registry or observational cohort study collecting structured data across many sites over yearsnot TherapyNotes
  • A small device sponsor that needs eConsent and ePRO in the same system as its case report formsnot TherapyNotes
  • An informatics group that wants to self-host the open source edition for a non-regulated internal studynot TherapyNotes

TherapyNotes

  • Patient Carenot OpenClinica
  • Medical Recordsnot OpenClinica
  • Practice Managementnot OpenClinica
  • Telehealthnot OpenClinica

Where each one falls short

Documented limitations, not opinions. Every one is a constraint you would hit in normal use.

OpenClinica

  • The free community edition is a different and older product line from the commercial platform, so evaluating the open source build tells you little about what the paid product actually does.
  • The vendor provides no support or services at all for the community edition, which means outages, patching, database upgrades and validation documentation are entirely your problem.
  • Commercial pricing is not published, so you cannot benchmark it against alternatives without entering a sales process, and third-party figures around USD 1,000 a month are indicative rather than contractual.
  • Study build is skilled work: complex edit checks, randomisation schemes and integrations usually mean paying for vendor or consultant configuration services on top of the licence, which is a frequently underestimated line in the budget.
  • As a smaller vendor than the large eClinical suites it has a thinner partner and consultant ecosystem, so finding experienced build staff or a CRO already fluent in the platform is harder than with the market incumbents.

TherapyNotes

  • No API access, preventing integration with external systems
  • Outdated interface compared to AI-driven competitors
  • No native mobile app for iOS or Android
  • No bulk actions to update multiple sessions at once

Pricing, plan by plan

OpenClinica

On request
  • Community Edition$undefined/year
    • Free and open source under the LGPL
    • Self-hosted, on the older 3.x line
    • No vendor support or services of any kind
  • OpenClinica Enterprise$undefined/year
    • Pricing only through a sales process
    • Hosted and validated instance
    • EDC, eConsent, eCOA, randomisation and analytics modules

TherapyNotes

$39/month
  • Solo$39/month
    • Full EHR
    • Scheduling
    • Patient portal

Which should you pick?

Choose OpenClinica if

  • You need open source community edition.
  • You work on Web, Self-hosted, iOS, Android.
  • You also want electronic data capture.
OpenClinica review

Choose TherapyNotes if

  • You need electronic health records.
  • You also want scheduling.
TherapyNotes review

Questions people ask

Is OpenClinica or TherapyNotes better?
Neither clearly leads. OpenClinica starts at On request and TherapyNotes at $39/month, and user ratings are close enough to be indistinguishable. Choose on capability and platform support.
Which is cheaper, OpenClinica or TherapyNotes?
OpenClinica starts at On request and TherapyNotes at $39/month.
Does OpenClinica or TherapyNotes run on more platforms?
OpenClinica runs on Web, Self-hosted, iOS, Android. TherapyNotes runs on Web.
What is OpenClinica best used for?
OpenClinica is most often used for an academic coordinating centre running investigator-initiated trials that needs part 11 compliant capture without an enterprise eclinical budget, a registry or observational cohort study collecting structured data across many sites over years, a small device sponsor that needs econsent and epro in the same system as its case report forms, an informatics group that wants to self-host the open source edition for a non-regulated internal study. Of those, an academic coordinating centre running investigator-initiated trials that needs part 11 compliant capture without an enterprise eclinical budget and a registry or observational cohort study collecting structured data across many sites over years are not what TherapyNotes is typically brought in for.
What can OpenClinica do that TherapyNotes cannot?
OpenClinica covers Open source community edition, Electronic data capture, eConsent, eCOA and ePRO. TherapyNotes covers Electronic Health Records, Scheduling, Billing, Patient Portal.

Answered from the vendors’ own pages

OpenClinica: Is OpenClinica free?

There is a genuinely free, LGPL licensed community edition you host yourself with no vendor support. The commercial platform with eConsent, eCOA and a validated hosted instance is quoted and paid.

TherapyNotes: Does TherapyNotes integrate with other applications?

TherapyNotes has zero API availability and cannot connect to external systems including marketing platforms, CRMs, or data dashboards. Unlike competitors, it lacks integration capabilities.

Source
OpenClinica: Is the open source version still maintained?

Yes, releases on the 3.x line continued through 2025, but it is a separate and older architecture from the commercial product.

TherapyNotes: What are TherapyNotes pricing plans?

TherapyNotes charges $69/month for a solo practitioner plan and $79/month for the first clinician in a group with $50/month per additional clinician. A 30-day free trial is included with every plan.

Source
OpenClinica: Does it meet 21 CFR Part 11?

The commercial hosted platform is built for Part 11 and GCP compliance. If you self-host the community edition, compliance and validation are entirely your responsibility.

TherapyNotes: Does TherapyNotes include telehealth?

Yes. TherapyNotes includes Basic Telehealth at no extra cost on every plan, with standard-definition video for up to 2 participants. Premium Telehealth with full HD, screen sharing, and closed captions costs $15 per clinician per month.

Source
OpenClinica: What does the commercial version cost?

Not published. Third-party listings suggest enterprise arrangements from around USD 1,000 per month, but real cost depends on study count, subjects, modules and build services.

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