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Healthcare · head to head

OpenClinica vs Tebra

OpenClinica logo

OpenClinica

Healthcare

Clinical trial EDC with a genuinely open source community edition alongside a quoted commercial platform

From
On request
Rated
-
Full reviewWebsite
Tebra logo

Tebra

Healthcare

Practice management combining EHR, billing and patient engagement for independent practices

From
On request
Rated
-
Full reviewWebsite

The short version

  • Each has a real cost: OpenClinica the free community edition is a different and older product line from the commercial platform, so evaluating the open source build tells you little about what the paid product actually does.; Tebra no pricing amounts published; custom quote required based on practice configuration
  • Prices and features above were last checked on 31 August 2026.

Where they differ

Only the attributes on which OpenClinica and Tebra actually diverge.

Attributes where OpenClinica and Tebra differ
AttributeOpenClinicaTebra
PlatformsWeb, Self-hosted, iOS, AndroidWeb

Identical on both: starting price (On request), pricing model (quote), free tier (No), user rating (Not yet rated), category (Healthcare).

What each one covers

Drawn from each product's published feature list. An absence here means we hold no record of it - not that the product lacks it.

Only in OpenClinica

  • Open source community edition
  • Electronic data capture
  • eConsent
  • eCOA and ePRO
  • Randomisation
  • EHR-to-EDC
  • Audit trail
  • Reporting and analytics

Only in Tebra

Nothing recorded that OpenClinica does not also cover.

What people use each for

The jobs each tool is most often brought in to do.

OpenClinica

  • An academic coordinating centre running investigator-initiated trials that needs Part 11 compliant capture without an enterprise eClinical budgetnot Tebra
  • A registry or observational cohort study collecting structured data across many sites over yearsnot Tebra
  • A small device sponsor that needs eConsent and ePRO in the same system as its case report formsnot Tebra
  • An informatics group that wants to self-host the open source edition for a non-regulated internal studynot Tebra

Tebra

  • Consolidating scheduling, charting, billing into single systemnot OpenClinica
  • Automating claims submission and denial managementnot OpenClinica
  • Reducing appointment no-shows through automated remindersnot OpenClinica
  • Reducing documentation time to five minutes with AInot OpenClinica
  • E-prescribing controlled substances with PDMP and EPCSnot OpenClinica

Where each one falls short

Documented limitations, not opinions. Every one is a constraint you would hit in normal use.

OpenClinica

  • The free community edition is a different and older product line from the commercial platform, so evaluating the open source build tells you little about what the paid product actually does.
  • The vendor provides no support or services at all for the community edition, which means outages, patching, database upgrades and validation documentation are entirely your problem.
  • Commercial pricing is not published, so you cannot benchmark it against alternatives without entering a sales process, and third-party figures around USD 1,000 a month are indicative rather than contractual.
  • Study build is skilled work: complex edit checks, randomisation schemes and integrations usually mean paying for vendor or consultant configuration services on top of the licence, which is a frequently underestimated line in the budget.
  • As a smaller vendor than the large eClinical suites it has a thinner partner and consultant ecosystem, so finding experienced build staff or a CRO already fluent in the platform is harder than with the market incumbents.

Tebra

  • No pricing amounts published; custom quote required based on practice configuration
  • Pricing based on per-provider licensing model with additional costs for EPCS setup and PDMP integration

Pricing, plan by plan

OpenClinica

On request
  • Community Edition$undefined/year
    • Free and open source under the LGPL
    • Self-hosted, on the older 3.x line
    • No vendor support or services of any kind
  • OpenClinica Enterprise$undefined/year
    • Pricing only through a sales process
    • Hosted and validated instance
    • EDC, eConsent, eCOA, randomisation and analytics modules

Tebra

On request

No published plan breakdown. See the Tebra review.

Which should you pick?

Choose OpenClinica if

  • You need open source community edition.
  • You work on Web, Self-hosted, iOS, Android.
  • You also want electronic data capture.
OpenClinica review

Choose Tebra if

Nothing in the data separates Tebra from OpenClinica on the points above - pick on price and on how each one feels to use.

Tebra review

Questions people ask

Is OpenClinica or Tebra better?
Neither clearly leads. OpenClinica starts at On request and Tebra at On request, and user ratings are close enough to be indistinguishable. Choose on capability and platform support.
Which is cheaper, OpenClinica or Tebra?
OpenClinica starts at On request and Tebra at On request.
Does OpenClinica or Tebra run on more platforms?
OpenClinica runs on Web, Self-hosted, iOS, Android. Tebra runs on Web.
What is OpenClinica best used for?
OpenClinica is most often used for an academic coordinating centre running investigator-initiated trials that needs part 11 compliant capture without an enterprise eclinical budget, a registry or observational cohort study collecting structured data across many sites over years, a small device sponsor that needs econsent and epro in the same system as its case report forms, an informatics group that wants to self-host the open source edition for a non-regulated internal study. Of those, an academic coordinating centre running investigator-initiated trials that needs part 11 compliant capture without an enterprise eclinical budget and a registry or observational cohort study collecting structured data across many sites over years are not what Tebra is typically brought in for.
What can OpenClinica do that Tebra cannot?
OpenClinica covers Open source community edition, Electronic data capture, eConsent, eCOA and ePRO.

Answered from the vendors’ own pages

OpenClinica: Is OpenClinica free?

There is a genuinely free, LGPL licensed community edition you host yourself with no vendor support. The commercial platform with eConsent, eCOA and a validated hosted instance is quoted and paid.

Tebra: How does Tebra's pricing model work?

Pricing is based on the number of clinical providers rather than user seats. Non-clinical staff get unlimited access at no additional cost. Low-volume providers billing under 100 claims monthly receive lower-tier pricing.

Source
OpenClinica: Is the open source version still maintained?

Yes, releases on the 3.x line continued through 2025, but it is a separate and older architecture from the commercial product.

Tebra: What are the setup and integration costs beyond the monthly fee?

Electronic Prescribing Controlled Substances (EPCS) setup costs approximately $75 per provider as a one-time fee. PDMP integration costs $500 one-time per facility plus approximately $50 per user per year.

Source
OpenClinica: Does it meet 21 CFR Part 11?

The commercial hosted platform is built for Part 11 and GCP compliance. If you self-host the community edition, compliance and validation are entirely your responsibility.

Tebra: Are there volume discounts for practices using multiple modules?

Yes, bundled pricing and volume incentives are available for multi-module adoption. Practices can request a personalized quote to see potential savings.

Source
OpenClinica: What does the commercial version cost?

Not published. Third-party listings suggest enterprise arrangements from around USD 1,000 per month, but real cost depends on study count, subjects, modules and build services.

Tebra: Does Tebra offer published pricing or is a quote always required?

Tebra does not publish specific monthly costs. Pricing varies depending on the number of providers, platform features needed, and implementation requirements. A personalized quote is required to get pricing.

Source
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