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Healthcare · head to head

OpenClinica vs RXNT

OpenClinica logo

OpenClinica

Healthcare

Clinical trial EDC with a genuinely open source community edition alongside a quoted commercial platform

From
On request
Rated
-
Full reviewWebsite
RXNT logo

RXNT

Healthcare

Cloud practice management and EHR software with a la carte modules

From
On request
Rated
-
Full reviewWebsite

The short version

  • Each has a real cost: OpenClinica the free community edition is a different and older product line from the commercial platform, so evaluating the open source build tells you little about what the paid product actually does.; RXNT specific pricing tiers not displayed; plans reference starting at $118/month
  • Prices and features above were last checked on 31 August 2026.

Where they differ

Only the attributes on which OpenClinica and RXNT actually diverge.

Attributes where OpenClinica and RXNT differ
AttributeOpenClinicaRXNT
Pricing modelquotesubscription
PlatformsWeb, Self-hosted, iOS, AndroidWeb

Identical on both: starting price (On request), free tier (No), user rating (Not yet rated), category (Healthcare).

What each one covers

Drawn from each product's published feature list. An absence here means we hold no record of it - not that the product lacks it.

Only in OpenClinica

  • Open source community edition
  • Electronic data capture
  • eConsent
  • eCOA and ePRO
  • Randomisation
  • EHR-to-EDC
  • Audit trail
  • Reporting and analytics

Only in RXNT

Nothing recorded that OpenClinica does not also cover.

What people use each for

The jobs each tool is most often brought in to do.

OpenClinica

  • An academic coordinating centre running investigator-initiated trials that needs Part 11 compliant capture without an enterprise eClinical budgetnot RXNT
  • A registry or observational cohort study collecting structured data across many sites over yearsnot RXNT
  • A small device sponsor that needs eConsent and ePRO in the same system as its case report formsnot RXNT
  • An informatics group that wants to self-host the open source edition for a non-regulated internal studynot RXNT

RXNT

  • Running entire medical practices from single integrated platformnot OpenClinica
  • Managing electronic prescriptions including controlled Schedule II-V drugsnot OpenClinica
  • Streamlining billing and claims management with unlimited claim processingnot OpenClinica
  • Supporting specialty workflows for mental health and hospice providersnot OpenClinica
  • Capturing appointment reminders and patient billing through patient portalnot OpenClinica

Where each one falls short

Documented limitations, not opinions. Every one is a constraint you would hit in normal use.

OpenClinica

  • The free community edition is a different and older product line from the commercial platform, so evaluating the open source build tells you little about what the paid product actually does.
  • The vendor provides no support or services at all for the community edition, which means outages, patching, database upgrades and validation documentation are entirely your problem.
  • Commercial pricing is not published, so you cannot benchmark it against alternatives without entering a sales process, and third-party figures around USD 1,000 a month are indicative rather than contractual.
  • Study build is skilled work: complex edit checks, randomisation schemes and integrations usually mean paying for vendor or consultant configuration services on top of the licence, which is a frequently underestimated line in the budget.
  • As a smaller vendor than the large eClinical suites it has a thinner partner and consultant ecosystem, so finding experienced build staff or a CRO already fluent in the platform is harder than with the market incumbents.

RXNT

  • Specific pricing tiers not displayed; plans reference starting at $118/month
  • E-prescribing only available with yearly subscription
  • Requires contacting sales for personalized pricing

Pricing, plan by plan

OpenClinica

On request
  • Community Edition$undefined/year
    • Free and open source under the LGPL
    • Self-hosted, on the older 3.x line
    • No vendor support or services of any kind
  • OpenClinica Enterprise$undefined/year
    • Pricing only through a sales process
    • Hosted and validated instance
    • EDC, eConsent, eCOA, randomisation and analytics modules

RXNT

On request

No published plan breakdown. See the RXNT review.

Which should you pick?

Choose OpenClinica if

  • You need open source community edition.
  • You work on Web, Self-hosted, iOS, Android.
  • You also want electronic data capture.
OpenClinica review

Choose RXNT if

Nothing in the data separates RXNT from OpenClinica on the points above - pick on price and on how each one feels to use.

RXNT review

Questions people ask

Is OpenClinica or RXNT better?
Neither clearly leads. OpenClinica starts at On request and RXNT at On request, and user ratings are close enough to be indistinguishable. Choose on capability and platform support.
Which is cheaper, OpenClinica or RXNT?
OpenClinica starts at On request and RXNT at On request.
Does OpenClinica or RXNT run on more platforms?
OpenClinica runs on Web, Self-hosted, iOS, Android. RXNT runs on Web.
What is OpenClinica best used for?
OpenClinica is most often used for an academic coordinating centre running investigator-initiated trials that needs part 11 compliant capture without an enterprise eclinical budget, a registry or observational cohort study collecting structured data across many sites over years, a small device sponsor that needs econsent and epro in the same system as its case report forms, an informatics group that wants to self-host the open source edition for a non-regulated internal study. Of those, an academic coordinating centre running investigator-initiated trials that needs part 11 compliant capture without an enterprise eclinical budget and a registry or observational cohort study collecting structured data across many sites over years are not what RXNT is typically brought in for.
What can OpenClinica do that RXNT cannot?
OpenClinica covers Open source community edition, Electronic data capture, eConsent, eCOA and ePRO.

Answered from the vendors’ own pages

OpenClinica: Is OpenClinica free?

There is a genuinely free, LGPL licensed community edition you host yourself with no vendor support. The commercial platform with eConsent, eCOA and a validated hosted instance is quoted and paid.

RXNT: What is RXNT's pricing model?

RXNT offers a-la-carte and bundled subscription options with monthly or annual billing. Annual subscriptions receive a 10% discount. Pricing starts at $118/month, though specific tier pricing is not displayed.

Source
OpenClinica: Is the open source version still maintained?

Yes, releases on the 3.x line continued through 2025, but it is a separate and older architecture from the commercial product.

RXNT: What are the additional costs for RXNT?

RXNT charges $85 per year for EPCS (Electronic Prescribing of Controlled Substances) including ID proofing and biometric authentication. Non-prescribing staff also have license fees, and data imports and extended onboarding are available at additional cost.

Source
OpenClinica: Does it meet 21 CFR Part 11?

The commercial hosted platform is built for Part 11 and GCP compliance. If you self-host the community edition, compliance and validation are entirely your responsibility.

RXNT: What onboarding support does RXNT provide?

RXNT includes 45 days of onboarding with the EHR Bundle and 60 days with the Practice Management and Full Suite bundles.

Source
OpenClinica: What does the commercial version cost?

Not published. Third-party listings suggest enterprise arrangements from around USD 1,000 per month, but real cost depends on study count, subjects, modules and build services.

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