Softwr

Healthcare · head to head

athenaOne vs OpenClinica

athenaOne logo

athenaOne

Healthcare

Unified cloud platform combining EHR, practice management, and patient engagement

From
$250/month
Rated
-
Full reviewWebsite
OpenClinica logo

OpenClinica

Healthcare

Clinical trial EDC with a genuinely open source community edition alongside a quoted commercial platform

From
On request
Rated
-
Full reviewWebsite

The short version

  • Each has a real cost: athenaOne no published pricing on homepage, pricing available through request for demo only; OpenClinica the free community edition is a different and older product line from the commercial platform, so evaluating the open source build tells you little about what the paid product actually does.
  • They diverge on capability: athenaOne covers Electronic Health Records, OpenClinica covers Open source community edition.
  • Prices and features above were last checked on 31 August 2026.

Where they differ

Only the attributes on which athenaOne and OpenClinica actually diverge.

Attributes where athenaOne and OpenClinica differ
AttributeathenaOneOpenClinica
Starting price$250/monthOn request
Pricing modelsubscriptionquote
PlatformsWeb, Mobile, ApiWeb, Self-hosted, iOS, Android
Founded1997Unknown

Identical on both: free tier (No), user rating (Not yet rated), category (Healthcare).

What each one covers

Drawn from each product's published feature list. An absence here means we hold no record of it - not that the product lacks it.

Only in athenaOne

  • Electronic Health Records
  • Practice Management
  • Patient Engagement
  • Care Coordination
  • Analytics
  • Mobile App
  • Telehealth
  • Labs

Only in OpenClinica

  • Open source community edition
  • Electronic data capture
  • eConsent
  • eCOA and ePRO
  • Randomisation
  • EHR-to-EDC
  • Audit trail
  • Reporting and analytics

What people use each for

The jobs each tool is most often brought in to do.

athenaOne

  • Patient Carenot OpenClinica
  • Medical Recordsnot OpenClinica
  • Practice Managementnot OpenClinica
  • Telehealthnot OpenClinica

OpenClinica

  • An academic coordinating centre running investigator-initiated trials that needs Part 11 compliant capture without an enterprise eClinical budgetnot athenaOne
  • A registry or observational cohort study collecting structured data across many sites over yearsnot athenaOne
  • A small device sponsor that needs eConsent and ePRO in the same system as its case report formsnot athenaOne
  • An informatics group that wants to self-host the open source edition for a non-regulated internal studynot athenaOne

Where each one falls short

Documented limitations, not opinions. Every one is a constraint you would hit in normal use.

athenaOne

  • No published pricing on homepage, pricing available through request for demo only
  • Healthcare EHR systems typically require enterprise-level contracts

OpenClinica

  • The free community edition is a different and older product line from the commercial platform, so evaluating the open source build tells you little about what the paid product actually does.
  • The vendor provides no support or services at all for the community edition, which means outages, patching, database upgrades and validation documentation are entirely your problem.
  • Commercial pricing is not published, so you cannot benchmark it against alternatives without entering a sales process, and third-party figures around USD 1,000 a month are indicative rather than contractual.
  • Study build is skilled work: complex edit checks, randomisation schemes and integrations usually mean paying for vendor or consultant configuration services on top of the licence, which is a frequently underestimated line in the budget.
  • As a smaller vendor than the large eClinical suites it has a thinner partner and consultant ecosystem, so finding experienced build staff or a CRO already fluent in the platform is harder than with the market incumbents.

Pricing, plan by plan

athenaOne

$250/month

No published plan breakdown. See the athenaOne review.

OpenClinica

On request
  • Community Edition$undefined/year
    • Free and open source under the LGPL
    • Self-hosted, on the older 3.x line
    • No vendor support or services of any kind
  • OpenClinica Enterprise$undefined/year
    • Pricing only through a sales process
    • Hosted and validated instance
    • EDC, eConsent, eCOA, randomisation and analytics modules

Which should you pick?

Choose athenaOne if

  • You need electronic health records.
  • You work on Web, Mobile, Api.
  • You also want practice management.
athenaOne review

Choose OpenClinica if

  • You need open source community edition.
  • You work on Web, Self-hosted, iOS, Android.
  • You also want electronic data capture.
OpenClinica review

Questions people ask

Is athenaOne or OpenClinica better?
Neither clearly leads. athenaOne starts at $250/month and OpenClinica at On request, and user ratings are close enough to be indistinguishable. Choose on capability and platform support.
Which is cheaper, athenaOne or OpenClinica?
athenaOne starts at $250/month and OpenClinica at On request.
Does athenaOne or OpenClinica run on more platforms?
athenaOne runs on Web, Mobile, Api. OpenClinica runs on Web, Self-hosted, iOS, Android.
What is athenaOne best used for?
athenaOne is most often used for patient care, medical records, practice management, telehealth. Of those, patient care and medical records are not what OpenClinica is typically brought in for.
What can athenaOne do that OpenClinica cannot?
athenaOne covers Electronic Health Records, Practice Management, Patient Engagement, Care Coordination. OpenClinica covers Open source community edition, Electronic data capture, eConsent, eCOA and ePRO.

Answered from the vendors’ own pages

athenaOne: What does athenaOne cost?

athenaOne does not publish pricing on their website. Organizations must contact their sales team or schedule a demo to receive a customized quote based on practice size, specialty, and required features.

Source
OpenClinica: Is OpenClinica free?

There is a genuinely free, LGPL licensed community edition you host yourself with no vendor support. The commercial platform with eConsent, eCOA and a validated hosted instance is quoted and paid.

OpenClinica: Is the open source version still maintained?

Yes, releases on the 3.x line continued through 2025, but it is a separate and older architecture from the commercial product.

OpenClinica: Does it meet 21 CFR Part 11?

The commercial hosted platform is built for Part 11 and GCP compliance. If you self-host the community edition, compliance and validation are entirely your responsibility.

OpenClinica: What does the commercial version cost?

Not published. Third-party listings suggest enterprise arrangements from around USD 1,000 per month, but real cost depends on study count, subjects, modules and build services.

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