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Healthcare · head to head

eClinicalWorks vs OpenClinica

eClinicalWorks logo

eClinicalWorks

Healthcare

Comprehensive EHR and practice management platform

From
On request
Rated
-
Full reviewWebsite
OpenClinica logo

OpenClinica

Healthcare

Clinical trial EDC with a genuinely open source community edition alongside a quoted commercial platform

From
On request
Rated
-
Full reviewWebsite

The short version

  • Each has a real cost: eClinicalWorks pricing details not disclosed on website; requires sales consultation or demo; OpenClinica the free community edition is a different and older product line from the commercial platform, so evaluating the open source build tells you little about what the paid product actually does.
  • They diverge on capability: eClinicalWorks covers Electronic Health Records, OpenClinica covers Open source community edition.
  • Prices and features above were last checked on 31 August 2026.

Where they differ

Only the attributes on which eClinicalWorks and OpenClinica actually diverge.

Attributes where eClinicalWorks and OpenClinica differ
AttributeeClinicalWorksOpenClinica
Pricing modelUnknownquote
PlatformsWeb, Cloud-basedWeb, Self-hosted, iOS, Android
Founded1999Unknown

Identical on both: starting price (On request), free tier (No), user rating (Not yet rated), category (Healthcare).

What each one covers

Drawn from each product's published feature list. An absence here means we hold no record of it - not that the product lacks it.

Only in eClinicalWorks

  • Electronic Health Records
  • Practice Management
  • Revenue Cycle
  • Patient Portal
  • ePrescribing
  • Telehealth
  • HL7
  • FHIR

Only in OpenClinica

  • Open source community edition
  • Electronic data capture
  • eConsent
  • eCOA and ePRO
  • Randomisation
  • EHR-to-EDC
  • Audit trail
  • Reporting and analytics

What people use each for

The jobs each tool is most often brought in to do.

eClinicalWorks

  • EHR and practice management for multi-specialty medical practicesnot OpenClinica
  • Patient engagement through telehealth (healow) and secure messagingnot OpenClinica
  • Revenue cycle management with 98%+ first-pass acceptance ratenot OpenClinica
  • AI-powered clinical documentation with Sunoh.ai medical scribenot OpenClinica

OpenClinica

  • An academic coordinating centre running investigator-initiated trials that needs Part 11 compliant capture without an enterprise eClinical budgetnot eClinicalWorks
  • A registry or observational cohort study collecting structured data across many sites over yearsnot eClinicalWorks
  • A small device sponsor that needs eConsent and ePRO in the same system as its case report formsnot eClinicalWorks
  • An informatics group that wants to self-host the open source edition for a non-regulated internal studynot eClinicalWorks

Where each one falls short

Documented limitations, not opinions. Every one is a constraint you would hit in normal use.

eClinicalWorks

  • Pricing details not disclosed on website; requires sales consultation or demo
  • No published technical system requirements specified
  • Cloud-based solution requires reliable internet connectivity for clinics

OpenClinica

  • The free community edition is a different and older product line from the commercial platform, so evaluating the open source build tells you little about what the paid product actually does.
  • The vendor provides no support or services at all for the community edition, which means outages, patching, database upgrades and validation documentation are entirely your problem.
  • Commercial pricing is not published, so you cannot benchmark it against alternatives without entering a sales process, and third-party figures around USD 1,000 a month are indicative rather than contractual.
  • Study build is skilled work: complex edit checks, randomisation schemes and integrations usually mean paying for vendor or consultant configuration services on top of the licence, which is a frequently underestimated line in the budget.
  • As a smaller vendor than the large eClinical suites it has a thinner partner and consultant ecosystem, so finding experienced build staff or a CRO already fluent in the platform is harder than with the market incumbents.

Pricing, plan by plan

eClinicalWorks

On request

No published plan breakdown. See the eClinicalWorks review.

OpenClinica

On request
  • Community Edition$undefined/year
    • Free and open source under the LGPL
    • Self-hosted, on the older 3.x line
    • No vendor support or services of any kind
  • OpenClinica Enterprise$undefined/year
    • Pricing only through a sales process
    • Hosted and validated instance
    • EDC, eConsent, eCOA, randomisation and analytics modules

Which should you pick?

Choose eClinicalWorks if

  • You need electronic health records.
  • You work on Web, Cloud-based.
  • You also want practice management.
eClinicalWorks review

Choose OpenClinica if

  • You need open source community edition.
  • You work on Web, Self-hosted, iOS, Android.
  • You also want electronic data capture.
OpenClinica review

Questions people ask

Is eClinicalWorks or OpenClinica better?
Neither clearly leads. eClinicalWorks starts at On request and OpenClinica at On request, and user ratings are close enough to be indistinguishable. Choose on capability and platform support.
Which is cheaper, eClinicalWorks or OpenClinica?
eClinicalWorks starts at On request and OpenClinica at On request.
Does eClinicalWorks or OpenClinica run on more platforms?
eClinicalWorks runs on Web, Cloud-based. OpenClinica runs on Web, Self-hosted, iOS, Android.
What is eClinicalWorks best used for?
eClinicalWorks is most often used for ehr and practice management for multi-specialty medical practices, patient engagement through telehealth (healow) and secure messaging, revenue cycle management with 98%+ first-pass acceptance rate, ai-powered clinical documentation with sunoh.ai medical scribe. Of those, ehr and practice management for multi-specialty medical practices and patient engagement through telehealth (healow) and secure messaging are not what OpenClinica is typically brought in for.
What can eClinicalWorks do that OpenClinica cannot?
eClinicalWorks covers Electronic Health Records, Practice Management, Revenue Cycle, Patient Portal. OpenClinica covers Open source community edition, Electronic data capture, eConsent, eCOA and ePRO.

Answered from the vendors’ own pages

eClinicalWorks: What does eClinicalWorks EHR cost per provider?

eClinicalWorks EHR costs $449/month per provider with no startup costs. This includes the electronic medical record system, mobile access, patient portal, messaging, document management, prescribing, reporting, and 24/7 support with cloud hosting.

Source
OpenClinica: Is OpenClinica free?

There is a genuinely free, LGPL licensed community edition you host yourself with no vendor support. The commercial platform with eConsent, eCOA and a validated hosted instance is quoted and paid.

eClinicalWorks: What is the cost of eClinicalWorks with Practice Management?

eClinicalWorks EHR with Practice Management costs $599/month per provider with no startup costs. This adds practice management functionality and billing implementation services.

Source
OpenClinica: Is the open source version still maintained?

Yes, releases on the 3.x line continued through 2025, but it is a separate and older architecture from the commercial product.

eClinicalWorks: What is eClinicalWorks' Revenue Cycle Management pricing?

eClinicalWorks RCM as a Service costs 2.9% of practice collections with no startup costs. It covers claim processing, denial management, appeals, and accounts receivable visibility.

Source
OpenClinica: Does it meet 21 CFR Part 11?

The commercial hosted platform is built for Part 11 and GCP compliance. If you self-host the community edition, compliance and validation are entirely your responsibility.

eClinicalWorks: Is there a cost for data migration to eClinicalWorks?

No, eClinicalWorks offers free data migration for practices switching from other EHR systems.

Source
OpenClinica: What does the commercial version cost?

Not published. Third-party listings suggest enterprise arrangements from around USD 1,000 per month, but real cost depends on study count, subjects, modules and build services.

eClinicalWorks: Are training costs included with eClinicalWorks?

Initial training is included for practices with 1-9 providers. Additional fees apply for larger practices.

Source
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