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Healthcare · head to head

SilverCloud by Amwell vs Therapixel

SilverCloud by Amwell logo

SilverCloud by Amwell

Healthcare

Guided digital cognitive behavioural therapy with a published randomised trial evidence base

From
On request
Rated
-
Full reviewWebsite
Therapixel logo

Therapixel

Healthcare

French mammography AI with FDA clearances for 2D and tomosynthesis breast screening

From
On request
Rated
-
Full reviewWebsite

The short version

  • Each has a real cost: SilverCloud by Amwell the evidence base is for the guided model, and organisations that deploy SilverCloud as unstaffed self service get the completion rates of unguided self help, which is not what the trials measured.; Therapixel european and American regulatory positions were established under different regimes, and under the EU Medical Device Regulation this class of diagnostic AI faces a higher classification and notified body scrutiny, so European buyers must verify the current MDR certificate and expiry rather than relying on a legacy CE reference.
  • They diverge on capability: SilverCloud by Amwell covers Guided programmes, Therapixel covers MammoScreen 2D.
  • Prices and features above were last checked on 1 September 2026.

Where they differ

Only the attributes on which SilverCloud by Amwell and Therapixel actually diverge.

Attributes where SilverCloud by Amwell and Therapixel differ
AttributeSilverCloud by AmwellTherapixel
PlatformsWeb, iOS, AndroidWeb

Identical on both: starting price (On request), pricing model (quote), free tier (No), user rating (Not yet rated), category (Healthcare).

What each one covers

Drawn from each product's published feature list. An absence here means we hold no record of it - not that the product lacks it.

Only in SilverCloud by Amwell

  • Guided programmes
  • Supporter review
  • Symptom measurement
  • Clinician dashboard
  • Risk detection
  • NHS talking therapies alignment
  • Multiple deployment models

Only in Therapixel

  • MammoScreen 2D
  • MammoScreen DBT
  • One to ten suspicion score
  • Summary report
  • Workstation and PACS delivery
  • Reading workflow configurations

What people use each for

The jobs each tool is most often brought in to do.

SilverCloud by Amwell

  • An NHS talking therapies service needing a digital option that fits national reporting requirements and reduces waiting list pressure for step two interventionsnot Therapixel
  • A health plan wanting a digital mental health offering it can defend to a clinical governance committee with peer reviewed trial evidencenot Therapixel
  • A university counselling service facing demand it cannot staff, using guided digital cognitive behavioural therapy as a first stepnot Therapixel
  • An employer that wants an evidence based clinical intervention rather than a wellbeing content librarynot Therapixel

Therapixel

  • A European breast screening programme running mandatory double reading that wants to evaluate AI as a concurrent or second reader within what national guidance permitsnot SilverCloud by Amwell
  • An American breast centre that has moved to tomosynthesis and needs reading support on DBT specifically, which Therapixel holds a clearance fornot SilverCloud by Amwell
  • A screening service wanting a graded suspicion score rather than a binary flag so readers can calibrate their own thresholdnot SilverCloud by Amwell
  • A radiology group evaluating multiple mammography AI vendors head to head on their own historic case set before committingnot SilverCloud by Amwell

Where each one falls short

Documented limitations, not opinions. Every one is a constraint you would hit in normal use.

SilverCloud by Amwell

  • The evidence base is for the guided model, and organisations that deploy SilverCloud as unstaffed self service get the completion rates of unguided self help, which is not what the trials measured.
  • Supporter capacity is normally the buyer responsibility rather than part of the licence, so the real cost includes trained staff time that does not appear on the software quote.
  • Digital cognitive behavioural therapy has substantial dropout across all vendors, so a service planning capacity from enrolment numbers rather than completion numbers will overstate the throughput gained.
  • It is now sold as part of the Amwell portfolio, and Amwell has restructured its product lines since acquiring SilverCloud, so buyers should ask how SilverCloud is positioned within the Amwell Converge platform and whether it can still be bought standalone.
  • Guided digital cognitive behavioural therapy is a step two intervention and does not serve moderate to severe presentations, so a service that buys it without a funded escalation pathway simply relocates the queue.

Therapixel

  • European and American regulatory positions were established under different regimes, and under the EU Medical Device Regulation this class of diagnostic AI faces a higher classification and notified body scrutiny, so European buyers must verify the current MDR certificate and expiry rather than relying on a legacy CE reference.
  • MammoScreen does mammography only, so a hospital wanting AI across head CT, chest and breast needs several vendors and several PACS integrations, or an orchestration layer bought from someone else.
  • Therapixel is a small French company competing against Hologic and iCAD, which have incumbency inside the mammography reading workstation, so integration into an American breast centre is more work than it is for the workstation vendor own AI.
  • Detection performance is sensitive to the mammography unit vendor and acquisition protocol, so published results do not transfer between estates and each site needs local validation it must fund itself.
  • Whether AI can substitute for one of two human readers is a national workforce and liability question, not a product capability, so the labour saving that justifies the purchase in one country is not permitted in another.

Pricing, plan by plan

SilverCloud by Amwell

On request
  • SilverCloud by Amwell$undefined/year
    • Priced per member per month or per completed course depending on the buyer type
    • Supporter capacity is usually provided by the buyer, not included in the licence
    • Programme library scope affects the rate

Therapixel

On request
  • MammoScreen$undefined/year
    • Priced per examination or by annual screening volume
    • 2D and tomosynthesis licensed by the versions cleared for each
    • Cloud or on premises deployment quoted differently

Which should you pick?

Choose SilverCloud by Amwell if

  • You need guided programmes.
  • You work on Web, iOS, Android.
  • You also want supporter review.
SilverCloud by Amwell review

Choose Therapixel if

  • You need mammoscreen 2d.
  • You also want mammoscreen dbt.
Therapixel review

Questions people ask

Is SilverCloud by Amwell or Therapixel better?
Neither clearly leads. SilverCloud by Amwell starts at On request and Therapixel at On request, and user ratings are close enough to be indistinguishable. Choose on capability and platform support.
Which is cheaper, SilverCloud by Amwell or Therapixel?
SilverCloud by Amwell starts at On request and Therapixel at On request.
Does SilverCloud by Amwell or Therapixel run on more platforms?
SilverCloud by Amwell runs on Web, iOS, Android. Therapixel runs on Web.
What is SilverCloud by Amwell best used for?
SilverCloud by Amwell is most often used for an nhs talking therapies service needing a digital option that fits national reporting requirements and reduces waiting list pressure for step two interventions, a health plan wanting a digital mental health offering it can defend to a clinical governance committee with peer reviewed trial evidence, a university counselling service facing demand it cannot staff, using guided digital cognitive behavioural therapy as a first step, an employer that wants an evidence based clinical intervention rather than a wellbeing content library. Of those, an nhs talking therapies service needing a digital option that fits national reporting requirements and reduces waiting list pressure for step two interventions and a health plan wanting a digital mental health offering it can defend to a clinical governance committee with peer reviewed trial evidence are not what Therapixel is typically brought in for.
What can SilverCloud by Amwell do that Therapixel cannot?
SilverCloud by Amwell covers Guided programmes, Supporter review, Symptom measurement, Clinician dashboard. Therapixel covers MammoScreen 2D, MammoScreen DBT, One to ten suspicion score, Summary report.

Answered from the vendors’ own pages

SilverCloud by Amwell: Is SilverCloud still available under its own name?

Yes. It is marketed as SilverCloud by Amwell and has its own product pages and NHS partnership, though contracting runs through Amwell.

Therapixel: Is MammoScreen FDA cleared?

Yes. It holds 510(k) clearance K192854 for two dimensional mammography from July 2020, a November 2021 clearance for digital breast tomosynthesis, and two further clearances in October 2024 for later versions.

SilverCloud by Amwell: What evidence supports it?

It has been evaluated in independently led randomised controlled trials, including a National Institute of Mental Health funded study published in Nature Human Behaviour in 2026 examining prevalence of mental disorders over two years at scale.

Therapixel: Is it CE marked?

Yes, but European buyers should ask specifically for the current certificate under the Medical Device Regulation and its expiry date, because this class of diagnostic AI moved to a higher classification under MDR.

SilverCloud by Amwell: Do we need to provide the supporters?

In most deployments, yes. The guided model requires trained supporter time, and that staffing is usually the buyer responsibility rather than included in the licence.

Therapixel: What does the one to ten score mean?

It is a graded suspicion score per finding and per study, designed to be integrated alongside a radiologist BI-RADS assessment rather than treated as a positive or negative result.

SilverCloud by Amwell: Is it suitable for severe presentations?

No. It is a step two style intervention for mild to moderate presentations, and it needs a funded escalation pathway for anything more severe.

Therapixel: Does it cover anything besides mammography?

No. It is a mammography product only, including tomosynthesis. Other body regions need a different vendor.

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