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Healthcare · head to head

eClinicalWorks Prime vs OpenClinica

eClinicalWorks Prime logo

eClinicalWorks Prime

Healthcare

AI-powered cloud EHR for modern healthcare practices

From
$180/month
Rated
-
Full reviewWebsite
OpenClinica logo

OpenClinica

Healthcare

Clinical trial EDC with a genuinely open source community edition alongside a quoted commercial platform

From
On request
Rated
-
Full reviewWebsite

The short version

  • Each has a real cost: eClinicalWorks Prime eHR Only is $449/month per provider and EHR with Practice Management is $599/month per provider, priced per provider rather than a flat practice fee; OpenClinica the free community edition is a different and older product line from the commercial platform, so evaluating the open source build tells you little about what the paid product actually does.
  • They diverge on capability: eClinicalWorks Prime covers Electronic Health Records, OpenClinica covers Open source community edition.
  • Prices and features above were last checked on 31 August 2026.

Where they differ

Only the attributes on which eClinicalWorks Prime and OpenClinica actually diverge.

Attributes where eClinicalWorks Prime and OpenClinica differ
AttributeeClinicalWorks PrimeOpenClinica
Starting price$180/monthOn request
Pricing modelsubscriptionquote
PlatformsWeb, Mobile, ApiWeb, Self-hosted, iOS, Android
Founded1999Unknown

Identical on both: free tier (No), user rating (Not yet rated), category (Healthcare).

What each one covers

Drawn from each product's published feature list. An absence here means we hold no record of it - not that the product lacks it.

Only in eClinicalWorks Prime

  • Electronic Health Records
  • AI-Assisted Documentation
  • Practice Management
  • Revenue Cycle
  • Patient Portal
  • Voice Recognition
  • Telehealth
  • HL7

Only in OpenClinica

  • Open source community edition
  • Electronic data capture
  • eConsent
  • eCOA and ePRO
  • Randomisation
  • EHR-to-EDC
  • Audit trail
  • Reporting and analytics

What people use each for

The jobs each tool is most often brought in to do.

eClinicalWorks Prime

  • Small to mid-size practices (1-9 providers) wanting per-provider EHR pricing with included trainingnot OpenClinica

OpenClinica

  • An academic coordinating centre running investigator-initiated trials that needs Part 11 compliant capture without an enterprise eClinical budgetnot eClinicalWorks Prime
  • A registry or observational cohort study collecting structured data across many sites over yearsnot eClinicalWorks Prime
  • A small device sponsor that needs eConsent and ePRO in the same system as its case report formsnot eClinicalWorks Prime
  • An informatics group that wants to self-host the open source edition for a non-regulated internal studynot eClinicalWorks Prime

Where each one falls short

Documented limitations, not opinions. Every one is a constraint you would hit in normal use.

eClinicalWorks Prime

  • EHR Only is $449/month per provider and EHR with Practice Management is $599/month per provider, priced per provider rather than a flat practice fee
  • The RCM as a Service option charges 2.9% of practice collections rather than a fixed fee
  • Practices with more than 9 providers are charged additional implementation fees beyond the included training

OpenClinica

  • The free community edition is a different and older product line from the commercial platform, so evaluating the open source build tells you little about what the paid product actually does.
  • The vendor provides no support or services at all for the community edition, which means outages, patching, database upgrades and validation documentation are entirely your problem.
  • Commercial pricing is not published, so you cannot benchmark it against alternatives without entering a sales process, and third-party figures around USD 1,000 a month are indicative rather than contractual.
  • Study build is skilled work: complex edit checks, randomisation schemes and integrations usually mean paying for vendor or consultant configuration services on top of the licence, which is a frequently underestimated line in the budget.
  • As a smaller vendor than the large eClinical suites it has a thinner partner and consultant ecosystem, so finding experienced build staff or a CRO already fluent in the platform is harder than with the market incumbents.

Pricing, plan by plan

eClinicalWorks Prime

$180/month

No published plan breakdown. See the eClinicalWorks Prime review.

OpenClinica

On request
  • Community Edition$undefined/year
    • Free and open source under the LGPL
    • Self-hosted, on the older 3.x line
    • No vendor support or services of any kind
  • OpenClinica Enterprise$undefined/year
    • Pricing only through a sales process
    • Hosted and validated instance
    • EDC, eConsent, eCOA, randomisation and analytics modules

Which should you pick?

Choose eClinicalWorks Prime if

  • You need electronic health records.
  • You work on Web, Mobile, Api.
  • You also want ai-assisted documentation.
eClinicalWorks Prime review

Choose OpenClinica if

  • You need open source community edition.
  • You work on Web, Self-hosted, iOS, Android.
  • You also want electronic data capture.
OpenClinica review

Questions people ask

Is eClinicalWorks Prime or OpenClinica better?
Neither clearly leads. eClinicalWorks Prime starts at $180/month and OpenClinica at On request, and user ratings are close enough to be indistinguishable. Choose on capability and platform support.
Which is cheaper, eClinicalWorks Prime or OpenClinica?
eClinicalWorks Prime starts at $180/month and OpenClinica at On request.
Does eClinicalWorks Prime or OpenClinica run on more platforms?
eClinicalWorks Prime runs on Web, Mobile, Api. OpenClinica runs on Web, Self-hosted, iOS, Android.
What is eClinicalWorks Prime best used for?
eClinicalWorks Prime is most often used for small to mid-size practices (1-9 providers) wanting per-provider ehr pricing with included training. Of those, small to mid-size practices (1-9 providers) wanting per-provider ehr pricing with included training is not what OpenClinica is typically brought in for.
What can eClinicalWorks Prime do that OpenClinica cannot?
eClinicalWorks Prime covers Electronic Health Records, AI-Assisted Documentation, Practice Management, Revenue Cycle. OpenClinica covers Open source community edition, Electronic data capture, eConsent, eCOA and ePRO.

Answered from the vendors’ own pages

eClinicalWorks Prime: How much does eClinicalWorks Prime cost?

eClinicalWorks does not publish pricing for its Prime RCM (Revenue Cycle Management) service. The vendor positions it as 'Better RCM service at a lower price than your current provider' but requires interested organizations to schedule a demo or contact sales at 508-836-2700 for custom pricing based on organizational size and specific requirements.

Source
OpenClinica: Is OpenClinica free?

There is a genuinely free, LGPL licensed community edition you host yourself with no vendor support. The commercial platform with eConsent, eCOA and a validated hosted instance is quoted and paid.

eClinicalWorks Prime: How can you get eClinicalWorks Prime pricing?

Contact eClinicalWorks directly at 508-836-2700 to speak with their sales team or schedule a demo to discuss pricing tailored to your organization.

Source
OpenClinica: Is the open source version still maintained?

Yes, releases on the 3.x line continued through 2025, but it is a separate and older architecture from the commercial product.

OpenClinica: Does it meet 21 CFR Part 11?

The commercial hosted platform is built for Part 11 and GCP compliance. If you self-host the community edition, compliance and validation are entirely your responsibility.

OpenClinica: What does the commercial version cost?

Not published. Third-party listings suggest enterprise arrangements from around USD 1,000 per month, but real cost depends on study count, subjects, modules and build services.

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