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Healthcare · head to head

athenaOne vs Signant Health

athenaOne logo

athenaOne

Healthcare

Unified cloud platform combining EHR, practice management, and patient engagement

From
$250/month
Rated
-
Full reviewWebsite
Signant Health logo

Signant Health

Healthcare

eCOA-first clinical trial platform that has grown outward into EDC, eConsent and televisits

From
On request
Rated
-
Full reviewWebsite

The short version

  • Each has a real cost: athenaOne no published pricing on homepage, pricing available through request for demo only; Signant Health no pricing is published, and the software licence is a minority of the real bill once instrument licensing, translations, device provisioning and services are added, so early budget estimates are routinely too low.
  • They diverge on capability: athenaOne covers Electronic Health Records, Signant Health covers eCOA and ePRO.
  • Prices and features above were last checked on 31 August 2026.

Where they differ

Only the attributes on which athenaOne and Signant Health actually diverge.

Attributes where athenaOne and Signant Health differ
AttributeathenaOneSignant Health
Starting price$250/monthOn request
Pricing modelsubscriptionquote
PlatformsWeb, Mobile, ApiWeb, iOS, Android
Founded1997Unknown

Identical on both: free tier (No), user rating (Not yet rated), category (Healthcare).

What each one covers

Drawn from each product's published feature list. An absence here means we hold no record of it - not that the product lacks it.

Only in athenaOne

  • Electronic Health Records
  • Practice Management
  • Patient Engagement
  • Care Coordination
  • Analytics
  • Mobile App
  • Telehealth
  • Labs

Only in Signant Health

  • eCOA and ePRO
  • Unified platform
  • eConsent
  • Randomisation and supplies
  • TeleVisits
  • Rater training
  • Data surveillance
  • Instrument library

What people use each for

The jobs each tool is most often brought in to do.

athenaOne

  • Patient Carenot Signant Health
  • Medical Recordsnot Signant Health
  • Practice Managementnot Signant Health
  • Telehealthnot Signant Health

Signant Health

  • A central nervous system or psychiatry trial where the primary endpoint is a rated scale and rater consistency decides the readoutnot athenaOne
  • A global study needing an outcome instrument translated and linguistically validated across a dozen languagesnot athenaOne
  • A decentralised or hybrid protocol combining televisits, eConsent and at-home patient reported outcomesnot athenaOne
  • A sponsor consolidating separate eCOA, eConsent and randomisation vendors onto one platform to cut reconciliation worknot athenaOne

Where each one falls short

Documented limitations, not opinions. Every one is a constraint you would hit in normal use.

athenaOne

  • No published pricing on homepage, pricing available through request for demo only
  • Healthcare EHR systems typically require enterprise-level contracts

Signant Health

  • No pricing is published, and the software licence is a minority of the real bill once instrument licensing, translations, device provisioning and services are added, so early budget estimates are routinely too low.
  • Linguistic validation is charged per instrument per language and is on the critical path to first patient in, so adding a country late in start-up produces both a cost and a schedule hit.
  • Provisioned participant devices bring logistics, replacement, shipping and cellular connectivity obligations that persist for the life of the trial and are frequently underestimated.
  • The EDC component is newer than the eCOA heritage, so sponsors with complex data management requirements often keep an incumbent EDC and lose the single-database benefit that justifies the platform.
  • It is priced and scoped for sponsor-grade trials, which makes it a poor fit for investigator-initiated or academic studies that need outcome collection without the services layer.

Pricing, plan by plan

athenaOne

$250/month

No published plan breakdown. See the athenaOne review.

Signant Health

On request
  • SmartSignals Unified Platform$undefined/year
    • Priced per study through a sales process
    • Modules selected per protocol: EDC, eCOA, randomisation, eConsent, TeleVisits
    • Instrument licensing paid to scale owners on top of platform cost

Which should you pick?

Choose athenaOne if

  • You need electronic health records.
  • You work on Web, Mobile, Api.
  • You also want practice management.
athenaOne review

Choose Signant Health if

  • You need ecoa and epro.
  • You work on Web, iOS, Android.
  • You also want unified platform.
Signant Health review

Questions people ask

Is athenaOne or Signant Health better?
Neither clearly leads. athenaOne starts at $250/month and Signant Health at On request, and user ratings are close enough to be indistinguishable. Choose on capability and platform support.
Which is cheaper, athenaOne or Signant Health?
athenaOne starts at $250/month and Signant Health at On request.
Does athenaOne or Signant Health run on more platforms?
athenaOne runs on Web, Mobile, Api. Signant Health runs on Web, iOS, Android.
What is athenaOne best used for?
athenaOne is most often used for patient care, medical records, practice management, telehealth. Of those, patient care and medical records are not what Signant Health is typically brought in for.
What can athenaOne do that Signant Health cannot?
athenaOne covers Electronic Health Records, Practice Management, Patient Engagement, Care Coordination. Signant Health covers eCOA and ePRO, Unified platform, eConsent, Randomisation and supplies.

Answered from the vendors’ own pages

athenaOne: What does athenaOne cost?

athenaOne does not publish pricing on their website. Organizations must contact their sales team or schedule a demo to receive a customized quote based on practice size, specialty, and required features.

Source
Signant Health: What is Signant best at?

Electronic clinical outcome assessment, particularly rated scales in central nervous system and psychiatry trials, together with rater training and endpoint quality services.

Signant Health: Is pricing published?

No. Everything is quoted per study, and instrument licences, translations and devices sit on top of the platform cost.

Signant Health: Can I use it only for eCOA?

Yes. The modules are selected per protocol, and many sponsors take eCOA and eConsent while keeping an existing EDC.

Signant Health: What drives the timeline?

Translation and linguistic validation of outcome instruments, which is per language per instrument and sits on the critical path to study start.

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