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Healthcare · head to head

Signant Health vs SilverCloud by Amwell

Signant Health logo

Signant Health

Healthcare

eCOA-first clinical trial platform that has grown outward into EDC, eConsent and televisits

From
On request
Rated
-
Full reviewWebsite
SilverCloud by Amwell logo

SilverCloud by Amwell

Healthcare

Guided digital cognitive behavioural therapy with a published randomised trial evidence base

From
On request
Rated
-
Full reviewWebsite

The short version

  • Each has a real cost: Signant Health no pricing is published, and the software licence is a minority of the real bill once instrument licensing, translations, device provisioning and services are added, so early budget estimates are routinely too low.; SilverCloud by Amwell the evidence base is for the guided model, and organisations that deploy SilverCloud as unstaffed self service get the completion rates of unguided self help, which is not what the trials measured.
  • They diverge on capability: Signant Health covers eCOA and ePRO, SilverCloud by Amwell covers Guided programmes.
  • Prices and features above were last checked on 1 September 2026.

Where they differ

Only the attributes on which Signant Health and SilverCloud by Amwell actually diverge.

Attributes where Signant Health and SilverCloud by Amwell differ
AttributeSignant HealthSilverCloud by Amwell

Identical on both: starting price (On request), pricing model (quote), free tier (No), platforms (Web, iOS, Android), user rating (Not yet rated), category (Healthcare).

What each one covers

Drawn from each product's published feature list. An absence here means we hold no record of it - not that the product lacks it.

Only in Signant Health

  • eCOA and ePRO
  • Unified platform
  • eConsent
  • Randomisation and supplies
  • TeleVisits
  • Rater training
  • Data surveillance
  • Instrument library

Only in SilverCloud by Amwell

  • Guided programmes
  • Supporter review
  • Symptom measurement
  • Clinician dashboard
  • Risk detection
  • NHS talking therapies alignment
  • Multiple deployment models

What people use each for

The jobs each tool is most often brought in to do.

Signant Health

  • A central nervous system or psychiatry trial where the primary endpoint is a rated scale and rater consistency decides the readoutnot SilverCloud by Amwell
  • A global study needing an outcome instrument translated and linguistically validated across a dozen languagesnot SilverCloud by Amwell
  • A decentralised or hybrid protocol combining televisits, eConsent and at-home patient reported outcomesnot SilverCloud by Amwell
  • A sponsor consolidating separate eCOA, eConsent and randomisation vendors onto one platform to cut reconciliation worknot SilverCloud by Amwell

SilverCloud by Amwell

  • An NHS talking therapies service needing a digital option that fits national reporting requirements and reduces waiting list pressure for step two interventionsnot Signant Health
  • A health plan wanting a digital mental health offering it can defend to a clinical governance committee with peer reviewed trial evidencenot Signant Health
  • A university counselling service facing demand it cannot staff, using guided digital cognitive behavioural therapy as a first stepnot Signant Health
  • An employer that wants an evidence based clinical intervention rather than a wellbeing content librarynot Signant Health

Where each one falls short

Documented limitations, not opinions. Every one is a constraint you would hit in normal use.

Signant Health

  • No pricing is published, and the software licence is a minority of the real bill once instrument licensing, translations, device provisioning and services are added, so early budget estimates are routinely too low.
  • Linguistic validation is charged per instrument per language and is on the critical path to first patient in, so adding a country late in start-up produces both a cost and a schedule hit.
  • Provisioned participant devices bring logistics, replacement, shipping and cellular connectivity obligations that persist for the life of the trial and are frequently underestimated.
  • The EDC component is newer than the eCOA heritage, so sponsors with complex data management requirements often keep an incumbent EDC and lose the single-database benefit that justifies the platform.
  • It is priced and scoped for sponsor-grade trials, which makes it a poor fit for investigator-initiated or academic studies that need outcome collection without the services layer.

SilverCloud by Amwell

  • The evidence base is for the guided model, and organisations that deploy SilverCloud as unstaffed self service get the completion rates of unguided self help, which is not what the trials measured.
  • Supporter capacity is normally the buyer responsibility rather than part of the licence, so the real cost includes trained staff time that does not appear on the software quote.
  • Digital cognitive behavioural therapy has substantial dropout across all vendors, so a service planning capacity from enrolment numbers rather than completion numbers will overstate the throughput gained.
  • It is now sold as part of the Amwell portfolio, and Amwell has restructured its product lines since acquiring SilverCloud, so buyers should ask how SilverCloud is positioned within the Amwell Converge platform and whether it can still be bought standalone.
  • Guided digital cognitive behavioural therapy is a step two intervention and does not serve moderate to severe presentations, so a service that buys it without a funded escalation pathway simply relocates the queue.

Pricing, plan by plan

Signant Health

On request
  • SmartSignals Unified Platform$undefined/year
    • Priced per study through a sales process
    • Modules selected per protocol: EDC, eCOA, randomisation, eConsent, TeleVisits
    • Instrument licensing paid to scale owners on top of platform cost

SilverCloud by Amwell

On request
  • SilverCloud by Amwell$undefined/year
    • Priced per member per month or per completed course depending on the buyer type
    • Supporter capacity is usually provided by the buyer, not included in the licence
    • Programme library scope affects the rate

Which should you pick?

Choose Signant Health if

  • You need ecoa and epro.
  • You work on Web, iOS, Android.
  • You also want unified platform.
Signant Health review

Choose SilverCloud by Amwell if

  • You need guided programmes.
  • You work on Web, iOS, Android.
  • You also want supporter review.
SilverCloud by Amwell review

Questions people ask

Is Signant Health or SilverCloud by Amwell better?
Neither clearly leads. Signant Health starts at On request and SilverCloud by Amwell at On request, and user ratings are close enough to be indistinguishable. Choose on capability and platform support.
Which is cheaper, Signant Health or SilverCloud by Amwell?
Signant Health starts at On request and SilverCloud by Amwell at On request.
Does Signant Health or SilverCloud by Amwell run on more platforms?
Both run on Web, iOS, Android, so platform support will not decide this one for you.
What is Signant Health best used for?
Signant Health is most often used for a central nervous system or psychiatry trial where the primary endpoint is a rated scale and rater consistency decides the readout, a global study needing an outcome instrument translated and linguistically validated across a dozen languages, a decentralised or hybrid protocol combining televisits, econsent and at-home patient reported outcomes, a sponsor consolidating separate ecoa, econsent and randomisation vendors onto one platform to cut reconciliation work. Of those, a central nervous system or psychiatry trial where the primary endpoint is a rated scale and rater consistency decides the readout and a global study needing an outcome instrument translated and linguistically validated across a dozen languages are not what SilverCloud by Amwell is typically brought in for.
What can Signant Health do that SilverCloud by Amwell cannot?
Signant Health covers eCOA and ePRO, Unified platform, eConsent, Randomisation and supplies. SilverCloud by Amwell covers Guided programmes, Supporter review, Symptom measurement, Clinician dashboard.

Answered from the vendors’ own pages

Signant Health: What is Signant best at?

Electronic clinical outcome assessment, particularly rated scales in central nervous system and psychiatry trials, together with rater training and endpoint quality services.

SilverCloud by Amwell: Is SilverCloud still available under its own name?

Yes. It is marketed as SilverCloud by Amwell and has its own product pages and NHS partnership, though contracting runs through Amwell.

Signant Health: Is pricing published?

No. Everything is quoted per study, and instrument licences, translations and devices sit on top of the platform cost.

SilverCloud by Amwell: What evidence supports it?

It has been evaluated in independently led randomised controlled trials, including a National Institute of Mental Health funded study published in Nature Human Behaviour in 2026 examining prevalence of mental disorders over two years at scale.

Signant Health: Can I use it only for eCOA?

Yes. The modules are selected per protocol, and many sponsors take eCOA and eConsent while keeping an existing EDC.

SilverCloud by Amwell: Do we need to provide the supporters?

In most deployments, yes. The guided model requires trained supporter time, and that staffing is usually the buyer responsibility rather than included in the licence.

Signant Health: What drives the timeline?

Translation and linguistic validation of outcome instruments, which is per language per instrument and sits on the critical path to study start.

SilverCloud by Amwell: Is it suitable for severe presentations?

No. It is a step two style intervention for mild to moderate presentations, and it needs a funded escalation pathway for anything more severe.

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