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Healthcare · head to head

Signant Health vs TheraNest

Signant Health logo

Signant Health

Healthcare

eCOA-first clinical trial platform that has grown outward into EDC, eConsent and televisits

From
On request
Rated
-
Full reviewWebsite
TheraNest logo

TheraNest

Healthcare

Mental health EHR and practice management priced per therapist

From
$29/month
Rated
-
Full reviewWebsite

The short version

  • Each has a real cost: Signant Health no pricing is published, and the software licence is a minority of the real bill once instrument licensing, translations, device provisioning and services are added, so early budget estimates are routinely too low.; TheraNest the Essentials plan includes no insurance claims at all, so any practice that bills a payer is effectively on the 59 USD tier or above and the advertised 29 USD entry price does not apply to it.
  • They diverge on capability: Signant Health covers eCOA and ePRO, TheraNest covers Progress notes and treatment plans.
  • Prices and features above were last checked on 31 August 2026.

Where they differ

Only the attributes on which Signant Health and TheraNest actually diverge.

Attributes where Signant Health and TheraNest differ
AttributeSignant HealthTheraNest
Starting priceOn request$29/month
Pricing modelquotePer user per month

Identical on both: free tier (No), platforms (Web, iOS, Android), user rating (Not yet rated), category (Healthcare).

What each one covers

Drawn from each product's published feature list. An absence here means we hold no record of it - not that the product lacks it.

Only in Signant Health

  • eCOA and ePRO
  • Unified platform
  • eConsent
  • Randomisation and supplies
  • TeleVisits
  • Rater training
  • Data surveillance
  • Instrument library

Only in TheraNest

  • Progress notes and treatment plans
  • Insurance claims
  • Client portal
  • Telehealth
  • Group and family sessions
  • Payroll and staff reporting

What people use each for

The jobs each tool is most often brought in to do.

Signant Health

  • A central nervous system or psychiatry trial where the primary endpoint is a rated scale and rater consistency decides the readoutnot TheraNest
  • A global study needing an outcome instrument translated and linguistically validated across a dozen languagesnot TheraNest
  • A decentralised or hybrid protocol combining televisits, eConsent and at-home patient reported outcomesnot TheraNest
  • A sponsor consolidating separate eCOA, eConsent and randomisation vendors onto one platform to cut reconciliation worknot TheraNest

TheraNest

  • A solo therapist who needs a HIPAA aligned note and scheduling system and does not bill insurance, where the 29 USD entry tier is genuinely sufficientnot Signant Health
  • A group practice of six to twenty clinicians that wants per clinician productivity and payroll reporting without buying a separate practice management layernot Signant Health
  • A practice moving off paper or a general purpose calendar that needs a client portal for intake forms and consent signaturesnot Signant Health
  • A behavioural health organisation that bills a steady volume of insurance claims each month and can size the Advanced allowance against its actual claim countnot Signant Health

Where each one falls short

Documented limitations, not opinions. Every one is a constraint you would hit in normal use.

Signant Health

  • No pricing is published, and the software licence is a minority of the real bill once instrument licensing, translations, device provisioning and services are added, so early budget estimates are routinely too low.
  • Linguistic validation is charged per instrument per language and is on the critical path to first patient in, so adding a country late in start-up produces both a cost and a schedule hit.
  • Provisioned participant devices bring logistics, replacement, shipping and cellular connectivity obligations that persist for the life of the trial and are frequently underestimated.
  • The EDC component is newer than the eCOA heritage, so sponsors with complex data management requirements often keep an incumbent EDC and lose the single-database benefit that justifies the platform.
  • It is priced and scoped for sponsor-grade trials, which makes it a poor fit for investigator-initiated or academic studies that need outcome collection without the services layer.

TheraNest

  • The Essentials plan includes no insurance claims at all, so any practice that bills a payer is effectively on the 59 USD tier or above and the advertised 29 USD entry price does not apply to it.
  • Telehealth is only in the Premier plan, so a practice that wants video sessions pays 89 USD per therapist per month even if it needs nothing else from that tier.
  • An annual AMA CPT licence fee is billed separately each December on top of subscription cost, which surprises practices that budgeted only the monthly figure.
  • Additional administrative users are chargeable, so a practice with front desk and billing staff who never see clients still pays 19 to 29 USD per head for people who generate no revenue.
  • The product sits inside a consolidated portfolio that has already renamed the parent company from Therapy Brands to Ensora Health, and product investment in a portfolio is directed by the owner rather than by this product line, so roadmap commitments are worth less than they would be from a single product vendor.

Pricing, plan by plan

Signant Health

On request
  • SmartSignals Unified Platform$undefined/year
    • Priced per study through a sales process
    • Modules selected per protocol: EDC, eCOA, randomisation, eConsent, TeleVisits
    • Instrument licensing paid to scale owners on top of platform cost

TheraNest

$29/month
  • Essentials$29/month
    • Per therapist
    • Scheduling and client portal
    • HIPAA aligned notes and documentation
  • Advanced$59/month
    • Per therapist
    • 30 insurance claims per month included
    • Custom forms
  • Premier$89/month
    • Per therapist
    • Unlimited insurance claims
    • Billing automation

Which should you pick?

Choose Signant Health if

  • You need ecoa and epro.
  • You work on Web, iOS, Android.
  • You also want unified platform.
Signant Health review

Choose TheraNest if

  • You need progress notes and treatment plans.
  • You work on Web, iOS, Android.
  • You also want insurance claims.
TheraNest review

Questions people ask

Is Signant Health or TheraNest better?
Neither clearly leads. Signant Health starts at On request and TheraNest at $29/month, and user ratings are close enough to be indistinguishable. Choose on capability and platform support.
Which is cheaper, Signant Health or TheraNest?
Signant Health starts at On request and TheraNest at $29/month.
Does Signant Health or TheraNest run on more platforms?
Both run on Web, iOS, Android, so platform support will not decide this one for you.
What is Signant Health best used for?
Signant Health is most often used for a central nervous system or psychiatry trial where the primary endpoint is a rated scale and rater consistency decides the readout, a global study needing an outcome instrument translated and linguistically validated across a dozen languages, a decentralised or hybrid protocol combining televisits, econsent and at-home patient reported outcomes, a sponsor consolidating separate ecoa, econsent and randomisation vendors onto one platform to cut reconciliation work. Of those, a central nervous system or psychiatry trial where the primary endpoint is a rated scale and rater consistency decides the readout and a global study needing an outcome instrument translated and linguistically validated across a dozen languages are not what TheraNest is typically brought in for.
What can Signant Health do that TheraNest cannot?
Signant Health covers eCOA and ePRO, Unified platform, eConsent, Randomisation and supplies. TheraNest covers Progress notes and treatment plans, Insurance claims, Client portal, Telehealth.

Answered from the vendors’ own pages

Signant Health: What is Signant best at?

Electronic clinical outcome assessment, particularly rated scales in central nervous system and psychiatry trials, together with rater training and endpoint quality services.

TheraNest: Is TheraNest still sold under that name?

Yes. The company rebranded from Therapy Brands to Ensora Health and the product is now marketed as TheraNest by Ensora Health, but you still buy TheraNest.

Signant Health: Is pricing published?

No. Everything is quoted per study, and instrument licences, translations and devices sit on top of the platform cost.

TheraNest: Can I bill insurance on the cheapest plan?

No. Essentials includes no claims. Advanced includes 30 claims a month and Premier is unlimited.

Signant Health: Can I use it only for eCOA?

Yes. The modules are selected per protocol, and many sponsors take eCOA and eConsent while keeping an existing EDC.

TheraNest: Are there hidden costs?

Two. Additional admin users are charged per head, and an AMA CPT licence fee is billed annually in December per therapist.

Signant Health: What drives the timeline?

Translation and linguistic validation of outcome instruments, which is per language per instrument and sits on the critical path to study start.

TheraNest: Does it support group practices?

Yes, with per clinician reporting and payroll figures, though every clinician and every admin is a paid seat.

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