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Research · head to head

OpenEye, Cadence Molecular Sciences vs Roam Research

OpenEye, Cadence Molecular Sciences logo

OpenEye, Cadence Molecular Sciences

Research

Computational chemistry toolkits and the Orion cloud platform, now inside Cadence

From
On request
Rated
-
Full reviewWebsite
Roam Research logo

Roam Research

Research

A note-taking tool for networked thought

From
$15/month
Rated
-
Full reviewWebsite

The short version

  • Each has a real cost: OpenEye, Cadence Molecular Sciences the free Public Domain Research Licence requires surrendering intellectual property rights and publishing results into the public domain, which rules it out for any academic group with a technology transfer office or patent ambitions.; Roam Research cloud-dependent: no local-first option, all data stored on Roam servers
  • They diverge on capability: OpenEye, Cadence Molecular Sciences covers OMEGA, Roam Research covers Bi-directional linking.
  • Prices and features above were last checked on 31 August 2026.

Where they differ

Only the attributes on which OpenEye, Cadence Molecular Sciences and Roam Research actually diverge.

Attributes where OpenEye, Cadence Molecular Sciences and Roam Research differ
AttributeOpenEye, Cadence Molecular SciencesRoam Research
Starting priceOn request$15/month
Pricing modelquoteUnknown
PlatformsLinux, Windows, macOS, Web, APIWeb, iOS, macOS, Windows
FoundedUnknown2017

Identical on both: free tier (No), user rating (Not yet rated), category (Research).

What each one covers

Drawn from each product's published feature list. An absence here means we hold no record of it - not that the product lacks it.

Only in OpenEye, Cadence Molecular Sciences

  • OMEGA
  • ROCS
  • ROCS X
  • Orion platform
  • Programmatic toolkits
  • Academic routes
  • Structure preparation
  • Docking and scoring

Only in Roam Research

  • Bi-directional linking
  • Block references
  • Daily notes
  • Graph visualization
  • Sidebar navigation
  • Version history
  • Markdown support
  • TODO management

What people use each for

The jobs each tool is most often brought in to do.

OpenEye, Cadence Molecular Sciences

  • A pharmaceutical discovery team screening a multi-billion compound library by three-dimensional shape rather than by two-dimensional similaritynot Roam Research
  • A computational chemist embedding conformer generation into an internal pipeline through the Python toolkitsnot Roam Research
  • A university group publishing openly that can accept the public domain licence terms in exchange for zero costnot Roam Research
  • A biotech scaling virtual screening on cloud compute without building its own clusternot Roam Research

Roam Research

  • Research notesnot OpenEye, Cadence Molecular Sciences
  • Writing projectsnot OpenEye, Cadence Molecular Sciences
  • Personal knowledge managementnot OpenEye, Cadence Molecular Sciences
  • Academic worknot OpenEye, Cadence Molecular Sciences
  • Creative thinkingnot OpenEye, Cadence Molecular Sciences

Where each one falls short

Documented limitations, not opinions. Every one is a constraint you would hit in normal use.

OpenEye, Cadence Molecular Sciences

  • The free Public Domain Research Licence requires surrendering intellectual property rights and publishing results into the public domain, which rules it out for any academic group with a technology transfer office or patent ambitions.
  • Free academic licences are renewable but re-evaluated annually with no guarantee of continuation, so a multi-year research programme has no assured software entitlement beyond the current year.
  • OpenEye now sits inside Cadence Design Systems, whose core business is chip design, so the roadmap and licensing culture are set by a company for which molecular sciences is one growth line among several.
  • Commercial pricing is entirely unpublished and structured as annual subscriptions with separate Orion compute, making total cost of a screening programme hard to forecast before contracting.
  • The toolkits assume real computational chemistry expertise; they are libraries and applications for specialists, not an interface a medicinal chemist can drive without training.

Roam Research

  • Cloud-dependent: no local-first option, all data stored on Roam servers
  • Offline sync issues: offline databases experience slow startup and synchronization problems
  • No native Android app
  • Requires internet connection for most functionality

Pricing, plan by plan

OpenEye, Cadence Molecular Sciences

On request
  • Commercial licence$undefined/year
    • Annual subscription priced through Cadence sales
    • Toolkits and applications licensed separately from the Orion platform
    • Orion compute billed on top of software entitlements
  • Academic Package$undefined/year
    • Paid annual subscription for university groups under ten members
    • Includes support
    • Researchers retain intellectual property rights
  • Public Domain Research LicenceFree
    • No cost
    • No support of any kind
    • No intellectual property rights retained

Roam Research

$15/month
  • Pro$15/month
    • Unlimited graphs
    • Unlimited blocks
    • Daily notes
  • Believer$500/5 years
    • All Pro features
    • Cost effective long-term subscription

Which should you pick?

Choose OpenEye, Cadence Molecular Sciences if

  • You need omega.
  • You work on Linux, Windows, macOS, Web, API.
  • You also want rocs.
OpenEye, Cadence Molecular Sciences review

Choose Roam Research if

  • You need bi-directional linking.
  • You work on Web, iOS, macOS, Windows.
  • You also want block references.
Roam Research review

Questions people ask

Is OpenEye, Cadence Molecular Sciences or Roam Research better?
Neither clearly leads. OpenEye, Cadence Molecular Sciences starts at On request and Roam Research at $15/month, and user ratings are close enough to be indistinguishable. Choose on capability and platform support.
Which is cheaper, OpenEye, Cadence Molecular Sciences or Roam Research?
OpenEye, Cadence Molecular Sciences starts at On request and Roam Research at $15/month.
Does OpenEye, Cadence Molecular Sciences or Roam Research run on more platforms?
OpenEye, Cadence Molecular Sciences runs on Linux, Windows, macOS, Web, API. Roam Research runs on Web, iOS, macOS, Windows.
What is OpenEye, Cadence Molecular Sciences best used for?
OpenEye, Cadence Molecular Sciences is most often used for a pharmaceutical discovery team screening a multi-billion compound library by three-dimensional shape rather than by two-dimensional similarity, a computational chemist embedding conformer generation into an internal pipeline through the python toolkits, a university group publishing openly that can accept the public domain licence terms in exchange for zero cost, a biotech scaling virtual screening on cloud compute without building its own cluster. Of those, a pharmaceutical discovery team screening a multi-billion compound library by three-dimensional shape rather than by two-dimensional similarity and a computational chemist embedding conformer generation into an internal pipeline through the python toolkits are not what Roam Research is typically brought in for.
What can OpenEye, Cadence Molecular Sciences do that Roam Research cannot?
OpenEye, Cadence Molecular Sciences covers OMEGA, ROCS, ROCS X, Orion platform. Roam Research covers Bi-directional linking, Block references, Daily notes, Graph visualization.

Answered from the vendors’ own pages

OpenEye, Cadence Molecular Sciences: Is OpenEye still OpenEye?

It trades as OpenEye, Cadence Molecular Sciences, and is part of Cadence Design Systems following acquisition. The product names OMEGA, ROCS and Orion continue.

Roam Research: Does Roam Research have a free plan?

No, Roam Research does not offer a free plan. However, it includes a 31-day free trial before requiring a subscription to either the Pro plan ($15/month) or Believer plan ($500 for five years).

Source
OpenEye, Cadence Molecular Sciences: Can academics use it for free?

Yes, through the Public Domain Research Licence or a Teaching Licence, but both come with no support and no intellectual property rights. Keeping IP rights and support requires the paid Academic Package.

Roam Research: Can I use Roam Research offline?

Roam Research has limited offline support. Offline databases have significant performance issues, including slow startup times and sync problems. The platform is cloud-dependent and requires internet connectivity for most functionality.

Source
OpenEye, Cadence Molecular Sciences: What is ROCS X?

A machine learning enabled extension of ROCS shape search, built on the Orion platform, aimed at screening chemical spaces in the trillions of molecules.

Roam Research: What platforms does Roam Research support?

Roam Research is available as a web app and native mobile apps for iOS and macOS. Windows users access it through the web app or Electron desktop wrapper. Android support is limited.

Source
OpenEye, Cadence Molecular Sciences: Is commercial pricing published?

No. Commercial licences are annual subscriptions quoted through Cadence sales, with Orion compute charged separately.

Roam Research: Can I export my data from Roam Research?

Yes, you can export your entire database or individual pages as JSON or Markdown format by clicking the three-dot menu. However, block references do not translate perfectly, and migration to other tools may require manual cleanup.

Source
Roam Research: Does Roam Research integrate with Slack?

Roam Research integrates with Slack through Zapier, allowing you to send Slack messages to Roam or add Slack messages to your Roam daily notes. No native Slack integration is available.

Source
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