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Research · head to head

OpenEye, Cadence Molecular Sciences vs Paperpile

OpenEye, Cadence Molecular Sciences logo

OpenEye, Cadence Molecular Sciences

Research

Computational chemistry toolkits and the Orion cloud platform, now inside Cadence

From
On request
Rated
-
Full reviewWebsite
Paperpile logo

Paperpile

Research

Reference management essentials

From
$4.15/month
Rated
-
Full reviewWebsite

The short version

  • Each has a real cost: OpenEye, Cadence Molecular Sciences the free Public Domain Research Licence requires surrendering intellectual property rights and publishing results into the public domain, which rules it out for any academic group with a technology transfer office or patent ambitions.; Paperpile no monthly billing option; annual billing only
  • Prices and features above were last checked on 31 August 2026.

Where they differ

Only the attributes on which OpenEye, Cadence Molecular Sciences and Paperpile actually diverge.

Attributes where OpenEye, Cadence Molecular Sciences and Paperpile differ
AttributeOpenEye, Cadence Molecular SciencesPaperpile
Starting priceOn request$4.15/month
Pricing modelquotesubscription
PlatformsLinux, Windows, macOS, Web, APIWeb

Identical on both: free tier (No), user rating (Not yet rated), category (Research).

What each one covers

Drawn from each product's published feature list. An absence here means we hold no record of it - not that the product lacks it.

Only in OpenEye, Cadence Molecular Sciences

  • OMEGA
  • ROCS
  • ROCS X
  • Orion platform
  • Programmatic toolkits
  • Academic routes
  • Structure preparation
  • Docking and scoring

Only in Paperpile

Nothing recorded that OpenEye, Cadence Molecular Sciences does not also cover.

What people use each for

The jobs each tool is most often brought in to do.

OpenEye, Cadence Molecular Sciences

  • A pharmaceutical discovery team screening a multi-billion compound library by three-dimensional shape rather than by two-dimensional similaritynot Paperpile
  • A computational chemist embedding conformer generation into an internal pipeline through the Python toolkitsnot Paperpile
  • A university group publishing openly that can accept the public domain licence terms in exchange for zero costnot Paperpile
  • A biotech scaling virtual screening on cloud compute without building its own clusternot Paperpile

Paperpile

  • Organizing research papers and managing academic citationsnot OpenEye, Cadence Molecular Sciences
  • Creating citations in multiple styles and BibTeX for writingnot OpenEye, Cadence Molecular Sciences
  • Collaborating on research through shared reference librariesnot OpenEye, Cadence Molecular Sciences
  • Integrating citations into Google Docs and Microsoft Wordnot OpenEye, Cadence Molecular Sciences

Where each one falls short

Documented limitations, not opinions. Every one is a constraint you would hit in normal use.

OpenEye, Cadence Molecular Sciences

  • The free Public Domain Research Licence requires surrendering intellectual property rights and publishing results into the public domain, which rules it out for any academic group with a technology transfer office or patent ambitions.
  • Free academic licences are renewable but re-evaluated annually with no guarantee of continuation, so a multi-year research programme has no assured software entitlement beyond the current year.
  • OpenEye now sits inside Cadence Design Systems, whose core business is chip design, so the roadmap and licensing culture are set by a company for which molecular sciences is one growth line among several.
  • Commercial pricing is entirely unpublished and structured as annual subscriptions with separate Orion compute, making total cost of a screening programme hard to forecast before contracting.
  • The toolkits assume real computational chemistry expertise; they are libraries and applications for specialists, not an interface a medicinal chemist can drive without training.

Paperpile

  • No monthly billing option; annual billing only
  • Regular plan lacks full-text PDF search and annotations
  • Safari and Firefox browser extensions currently in beta
  • Chrome signup initially required

Pricing, plan by plan

OpenEye, Cadence Molecular Sciences

On request
  • Commercial licence$undefined/year
    • Annual subscription priced through Cadence sales
    • Toolkits and applications licensed separately from the Orion platform
    • Orion compute billed on top of software entitlements
  • Academic Package$undefined/year
    • Paid annual subscription for university groups under ten members
    • Includes support
    • Researchers retain intellectual property rights
  • Public Domain Research LicenceFree
    • No cost
    • No support of any kind
    • No intellectual property rights retained

Paperpile

$4.15/month
  • Regular$4.15/month
    • Basic reference management
    • PDF storage and citation generation
    • Integrations with Word, Google Docs, and academic databases
  • Expert$5.75/month
    • All Regular features
    • Full-text PDF search
    • Notes and annotations

Which should you pick?

Choose OpenEye, Cadence Molecular Sciences if

  • You need omega.
  • You work on Linux, Windows, macOS, Web, API.
  • You also want rocs.
OpenEye, Cadence Molecular Sciences review

Choose Paperpile if

Nothing in the data separates Paperpile from OpenEye, Cadence Molecular Sciences on the points above - pick on price and on how each one feels to use.

Paperpile review

Questions people ask

Is OpenEye, Cadence Molecular Sciences or Paperpile better?
Neither clearly leads. OpenEye, Cadence Molecular Sciences starts at On request and Paperpile at $4.15/month, and user ratings are close enough to be indistinguishable. Choose on capability and platform support.
Which is cheaper, OpenEye, Cadence Molecular Sciences or Paperpile?
OpenEye, Cadence Molecular Sciences starts at On request and Paperpile at $4.15/month.
Does OpenEye, Cadence Molecular Sciences or Paperpile run on more platforms?
OpenEye, Cadence Molecular Sciences runs on Linux, Windows, macOS, Web, API. Paperpile runs on Web.
What is OpenEye, Cadence Molecular Sciences best used for?
OpenEye, Cadence Molecular Sciences is most often used for a pharmaceutical discovery team screening a multi-billion compound library by three-dimensional shape rather than by two-dimensional similarity, a computational chemist embedding conformer generation into an internal pipeline through the python toolkits, a university group publishing openly that can accept the public domain licence terms in exchange for zero cost, a biotech scaling virtual screening on cloud compute without building its own cluster. Of those, a pharmaceutical discovery team screening a multi-billion compound library by three-dimensional shape rather than by two-dimensional similarity and a computational chemist embedding conformer generation into an internal pipeline through the python toolkits are not what Paperpile is typically brought in for.
What can OpenEye, Cadence Molecular Sciences do that Paperpile cannot?
OpenEye, Cadence Molecular Sciences covers OMEGA, ROCS, ROCS X, Orion platform.

Answered from the vendors’ own pages

OpenEye, Cadence Molecular Sciences: Is OpenEye still OpenEye?

It trades as OpenEye, Cadence Molecular Sciences, and is part of Cadence Design Systems following acquisition. The product names OMEGA, ROCS and Orion continue.

Paperpile: How much does Paperpile cost?

Paperpile costs $4.15 per month for the Regular plan or $5.75 per month for the Expert plan, both billed annually.

Source
OpenEye, Cadence Molecular Sciences: Can academics use it for free?

Yes, through the Public Domain Research Licence or a Teaching Licence, but both come with no support and no intellectual property rights. Keeping IP rights and support requires the paid Academic Package.

Paperpile: Is there a free trial available for Paperpile?

Yes, Paperpile offers a 30-day free trial for both plans.

Source
OpenEye, Cadence Molecular Sciences: What is ROCS X?

A machine learning enabled extension of ROCS shape search, built on the Orion platform, aimed at screening chemical spaces in the trillions of molecules.

Paperpile: Does Paperpile offer academic or group discounts?

Yes, students, faculty, and researchers receive 50% off, and group discounts up to 20% off Expert plans are available when purchasing multiple seats.

Source
OpenEye, Cadence Molecular Sciences: Is commercial pricing published?

No. Commercial licences are annual subscriptions quoted through Cadence sales, with Orion compute charged separately.

Paperpile: What billing options does Paperpile offer?

Paperpile accepts credit cards and PayPal, with additional payment options by location. Purchase orders are accepted for Enterprise customers.

Source
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