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Healthcare · head to head

Cerner PowerWorks vs OpenClinica

Cerner PowerWorks logo

Cerner PowerWorks

Healthcare

Revenue cycle management and financial solutions from Cerner

From
On request
Rated
-
Full reviewWebsite
OpenClinica logo

OpenClinica

Healthcare

Clinical trial EDC with a genuinely open source community edition alongside a quoted commercial platform

From
On request
Rated
-
Full reviewWebsite

The short version

  • They diverge on capability: Cerner PowerWorks covers Medical Coding, OpenClinica covers Open source community edition.
  • Prices and features above were last checked on 31 August 2026.

Where they differ

Only the attributes on which Cerner PowerWorks and OpenClinica actually diverge.

Attributes where Cerner PowerWorks and OpenClinica differ
AttributeCerner PowerWorksOpenClinica
PlatformsWeb, DesktopWeb, Self-hosted, iOS, Android
Founded1979Unknown

Identical on both: starting price (On request), pricing model (quote), free tier (No), user rating (Not yet rated), category (Healthcare).

What each one covers

Drawn from each product's published feature list. An absence here means we hold no record of it - not that the product lacks it.

Only in Cerner PowerWorks

  • Medical Coding
  • Charge Capture
  • Claims Management
  • Accounts Receivable
  • Financial Analytics
  • Billing Integration
  • Clearinghouses
  • Insurance Plans

Only in OpenClinica

  • Open source community edition
  • Electronic data capture
  • eConsent
  • eCOA and ePRO
  • Randomisation
  • EHR-to-EDC
  • Audit trail
  • Reporting and analytics

What people use each for

The jobs each tool is most often brought in to do.

Cerner PowerWorks

  • Patient Carenot OpenClinica
  • Medical Recordsnot OpenClinica
  • Practice Managementnot OpenClinica
  • Telehealthnot OpenClinica

OpenClinica

  • An academic coordinating centre running investigator-initiated trials that needs Part 11 compliant capture without an enterprise eClinical budgetnot Cerner PowerWorks
  • A registry or observational cohort study collecting structured data across many sites over yearsnot Cerner PowerWorks
  • A small device sponsor that needs eConsent and ePRO in the same system as its case report formsnot Cerner PowerWorks
  • An informatics group that wants to self-host the open source edition for a non-regulated internal studynot Cerner PowerWorks

Where each one falls short

Documented limitations, not opinions. Every one is a constraint you would hit in normal use.

Cerner PowerWorks

Nothing recorded yet. See the Cerner PowerWorks review.

OpenClinica

  • The free community edition is a different and older product line from the commercial platform, so evaluating the open source build tells you little about what the paid product actually does.
  • The vendor provides no support or services at all for the community edition, which means outages, patching, database upgrades and validation documentation are entirely your problem.
  • Commercial pricing is not published, so you cannot benchmark it against alternatives without entering a sales process, and third-party figures around USD 1,000 a month are indicative rather than contractual.
  • Study build is skilled work: complex edit checks, randomisation schemes and integrations usually mean paying for vendor or consultant configuration services on top of the licence, which is a frequently underestimated line in the budget.
  • As a smaller vendor than the large eClinical suites it has a thinner partner and consultant ecosystem, so finding experienced build staff or a CRO already fluent in the platform is harder than with the market incumbents.

Pricing, plan by plan

Cerner PowerWorks

On request

No published plan breakdown. See the Cerner PowerWorks review.

OpenClinica

On request
  • Community Edition$undefined/year
    • Free and open source under the LGPL
    • Self-hosted, on the older 3.x line
    • No vendor support or services of any kind
  • OpenClinica Enterprise$undefined/year
    • Pricing only through a sales process
    • Hosted and validated instance
    • EDC, eConsent, eCOA, randomisation and analytics modules

Which should you pick?

Choose Cerner PowerWorks if

  • You need medical coding.
  • You work on Web, Desktop.
  • You also want charge capture.
Cerner PowerWorks review

Choose OpenClinica if

  • You need open source community edition.
  • You work on Web, Self-hosted, iOS, Android.
  • You also want electronic data capture.
OpenClinica review

Questions people ask

Is Cerner PowerWorks or OpenClinica better?
Neither clearly leads. Cerner PowerWorks starts at On request and OpenClinica at On request, and user ratings are close enough to be indistinguishable. Choose on capability and platform support.
Which is cheaper, Cerner PowerWorks or OpenClinica?
Cerner PowerWorks starts at On request and OpenClinica at On request.
Does Cerner PowerWorks or OpenClinica run on more platforms?
Cerner PowerWorks runs on Web, Desktop. OpenClinica runs on Web, Self-hosted, iOS, Android.
What is Cerner PowerWorks best used for?
Cerner PowerWorks is most often used for patient care, medical records, practice management, telehealth. Of those, patient care and medical records are not what OpenClinica is typically brought in for.
What can Cerner PowerWorks do that OpenClinica cannot?
Cerner PowerWorks covers Medical Coding, Charge Capture, Claims Management, Accounts Receivable. OpenClinica covers Open source community edition, Electronic data capture, eConsent, eCOA and ePRO.

Answered from the vendors’ own pages

OpenClinica: Is OpenClinica free?

There is a genuinely free, LGPL licensed community edition you host yourself with no vendor support. The commercial platform with eConsent, eCOA and a validated hosted instance is quoted and paid.

OpenClinica: Is the open source version still maintained?

Yes, releases on the 3.x line continued through 2025, but it is a separate and older architecture from the commercial product.

OpenClinica: Does it meet 21 CFR Part 11?

The commercial hosted platform is built for Part 11 and GCP compliance. If you self-host the community edition, compliance and validation are entirely your responsibility.

OpenClinica: What does the commercial version cost?

Not published. Third-party listings suggest enterprise arrangements from around USD 1,000 per month, but real cost depends on study count, subjects, modules and build services.

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