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Cybersecurity · head to head

Microsoft Defender for Endpoint vs Proofpoint

Microsoft Defender for Endpoint logo

Microsoft Defender for Endpoint

Cybersecurity

Enterprise endpoint security built into Microsoft 365

From
On request
Rated
-
Full reviewWebsite
Proofpoint logo

Proofpoint

Cybersecurity

Email security and data protection suite from a private company owned by Thoma Bravo, licensed per user with modules sold separately.

From
$6/month
Rated
-
Full reviewWebsite

The short version

  • Each has a real cost: Microsoft Defender for Endpoint pricing not published on public websites; quote required from Microsoft sales; Proofpoint licensing is per user per year with each capability as a separate stock item, so the platform shown in a proof of concept is normally several products, and adding awareness training, data loss prevention or insider threat monitoring later is a fresh negotiation rather than enabling a feature.
  • They diverge on capability: Microsoft Defender for Endpoint covers Threat & vulnerability management, Proofpoint covers Inline secure email gateway.
  • Prices and features above were last checked on 30 August 2026.

Where they differ

Only the attributes on which Microsoft Defender for Endpoint and Proofpoint actually diverge.

Attributes where Microsoft Defender for Endpoint and Proofpoint differ
AttributeMicrosoft Defender for EndpointProofpoint
Starting priceOn request$6/month
Pricing modelquotesubscription
PlatformsWindows, macOS, Linux, iOS, AndroidEmail, Cloud, Web
Founded19752002

Identical on both: free tier (No), user rating (Not yet rated), category (Cybersecurity).

What each one covers

Drawn from each product's published feature list. An absence here means we hold no record of it - not that the product lacks it.

Only in Microsoft Defender for Endpoint

  • Threat & vulnerability management
  • Attack surface reduction
  • Next-gen protection
  • EDR
  • Auto investigation
  • Microsoft Threat Experts
  • Threat analytics
  • Secure score

Only in Proofpoint

  • Inline secure email gateway
  • Attachment sandboxing
  • URL rewriting and click-time analysis
  • Threat Response Auto-Pull
  • Email Fraud Defense
  • Security awareness training
  • Insider Threat Management
  • Enterprise DLP

What people use each for

The jobs each tool is most often brought in to do.

Microsoft Defender for Endpoint

  • Enterprise endpoint security across Windows, macOS, Linux, Android, and iOS via Plans 1 or 2not Proofpoint
  • Small and medium-sized businesses using Microsoft Defender for Business as alternativenot Proofpoint
  • Organisations using Microsoft 365 E5 which includes Defender for Endpoint Plan 2not Proofpoint

Proofpoint

  • A regulated organisation that needs a filtering layer, DMARC enforcement and archiving with an auditable trail across all threenot Microsoft Defender for Endpoint
  • An organisation that suffered a business email compromise and must show its board a control that stops delivery rather than remediating afterwardsnot Microsoft Defender for Endpoint
  • Concentrating stronger controls and training on the specific individuals who actually receive targeted attacks rather than applying uniform policynot Microsoft Defender for Endpoint
  • Retracting a phishing message from thousands of mailboxes after the verdict changes, including copies that were forwarded internallynot Microsoft Defender for Endpoint

Where each one falls short

Documented limitations, not opinions. Every one is a constraint you would hit in normal use.

Microsoft Defender for Endpoint

  • Pricing not published on public websites; quote required from Microsoft sales
  • Defender for Endpoint Plan 1 and Plan 2 do not include server licenses; additional licensing required for server protection
  • Specific feature differences between Plan 1 and Plan 2 require consulting Microsoft documentation

Proofpoint

  • Licensing is per user per year with each capability as a separate stock item, so the platform shown in a proof of concept is normally several products, and adding awareness training, data loss prevention or insider threat monitoring later is a fresh negotiation rather than enabling a feature.
  • It sits inline with MX records pointed at it, so any service degradation is a mail outage for the entire organisation, and both migrating on and migrating off are cutovers with queueing, rollback planning and a real risk of message loss.
  • Most customers on Microsoft 365 E5 or Google Workspace Enterprise are already paying for native filtering, so Proofpoint is a second licence layered over a capability the organisation owns, and that comparison is raised by finance at every single renewal.
  • The administration console carries a decade of acquisitions: the classic gateway policy routes and filters do not share a model with the newer module interfaces, rule evaluation is order-sensitive in ways that surprise untrained administrators, and mistakes there silently change what is delivered.
  • Quarantine management is a standing helpdesk workload because legitimate bulk mail, invoices and supplier notifications are held, and unless end-user digests are configured and users are taught to use them, the security team becomes the mail release desk.

Pricing, plan by plan

Microsoft Defender for Endpoint

On request

No published plan breakdown. See the Microsoft Defender for Endpoint review.

Proofpoint

$6/month
  • Email Protection$6/month
    • Per user
    • Advanced threat detection
    • Data loss prevention
  • Compliance$8/month
    • All Email Protection
    • Archive & search
    • eDiscovery
  • Advanced Threat$10/month
    • All Compliance features
    • Targeted attack detection
    • Behavior analytics

Which should you pick?

Choose Microsoft Defender for Endpoint if

  • You need threat & vulnerability management.
  • You work on Windows, macOS, Linux, iOS, Android.
  • You also want attack surface reduction.
Microsoft Defender for Endpoint review

Choose Proofpoint if

  • You need inline secure email gateway.
  • You work on Email, Cloud, Web.
  • You also want attachment sandboxing.
Proofpoint review

Questions people ask

Is Microsoft Defender for Endpoint or Proofpoint better?
Neither clearly leads. Microsoft Defender for Endpoint starts at On request and Proofpoint at $6/month, and user ratings are close enough to be indistinguishable. Choose on capability and platform support.
Which is cheaper, Microsoft Defender for Endpoint or Proofpoint?
Microsoft Defender for Endpoint starts at On request and Proofpoint at $6/month.
Does Microsoft Defender for Endpoint or Proofpoint run on more platforms?
Microsoft Defender for Endpoint runs on Windows, macOS, Linux, iOS, Android. Proofpoint runs on Email, Cloud, Web.
What is Microsoft Defender for Endpoint best used for?
Microsoft Defender for Endpoint is most often used for enterprise endpoint security across windows, macos, linux, android, and ios via plans 1 or 2, small and medium-sized businesses using microsoft defender for business as alternative, organisations using microsoft 365 e5 which includes defender for endpoint plan 2. Of those, enterprise endpoint security across windows, macos, linux, android, and ios via plans 1 or 2 and small and medium-sized businesses using microsoft defender for business as alternative are not what Proofpoint is typically brought in for.
What can Microsoft Defender for Endpoint do that Proofpoint cannot?
Microsoft Defender for Endpoint covers Threat & vulnerability management, Attack surface reduction, Next-gen protection, EDR. Proofpoint covers Inline secure email gateway, Attachment sandboxing, URL rewriting and click-time analysis, Threat Response Auto-Pull.

Answered from the vendors’ own pages

Microsoft Defender for Endpoint: How is Microsoft Defender for Endpoint priced?

Defender for Endpoint is bundled into Microsoft 365 enterprise subscriptions. Plan 1 is included in Microsoft 365 E3, and Plan 2 is included in Microsoft 365 E5. Individual pricing is not published separately.

Source
Proofpoint: Does it replace Microsoft Defender for Office 365?

Functionally it overlaps heavily, and running both means paying twice for filtering. Most Proofpoint customers on Microsoft 365 keep Defender licensed because it is bundled in E5 and use Proofpoint as the inline gateway. Expect to justify that duplication annually.

Microsoft Defender for Endpoint: Does Microsoft Defender for Endpoint offer a trial?

Yes. A free trial is available for prospective customers to test the product before committing to a subscription.

Source
Proofpoint: Who owns Proofpoint?

Thoma Bravo, a private equity firm, which took the company private in 2021. It has continued to acquire since, including Tessian, Normalyze and Hornetsecurity, which is why the portfolio spans so many adjacent categories.

Microsoft Defender for Endpoint: What is the difference between Plan 1 and Plan 2?

Plan 1 (in E3) includes unified security tools, device controls, network protection, firewall, web/URL controls, APIs, SIEM connectors, and app controls. Plan 2 (in E5) adds endpoint detection and response, deception techniques, automatic attack disruption, exposure management, and threat intelligence.

Source
Proofpoint: Do I have to change my MX records?

For the gateway, yes. That is what makes it inline and able to block before delivery. Some newer capabilities integrate through the mailbox API instead, but the core protection model is MX-level.

Proofpoint: Is security awareness training included?

No, it is a separate subscription. It integrates well with the threat data, so training can target the users actually being attacked, but it is a distinct line item on the quote.

Proofpoint: What does Threat Response Auto-Pull actually do?

It removes messages from mailboxes after delivery when the verdict changes, including copies that users forwarded internally. It is the answer to the case where a link was clean at delivery and weaponised an hour later.

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